Reproductive disorders are common events in modern reproductive medicine, occurring both in spontaneous and assisted pregnancies. Studies on the molecular mechanisms of implantation disorders in thin endometria, including the study of gene transcriptional activities, have shed light on the identification of the potential biological markers of endometrial receptivity. : The goal of this study was to reveal the significantly dysregulated selected gene expressions between RIF and RPL patients with thin endometria. : Endometrial samples were collected from RIF patients ( = 20) and RPL patients ( = 19) during the implantation window days (LH + 7-LH + 10) of their natural menstrual cycles. Ten genes were chosen as the target genes regarding their possible relations with the implantation process. The total RNA was purified and reverse-transcribed, and gene expressions were quantified by RT-PCR. : The expressions of the , , and genes were significantly decreased in the RIF patients with thin endometria compared to the RPL patients (log fold change = 0.92, = 0.023 for ; log fold change = 1.24, = 0.046 for ; and log fold change = 0.579, = 0.046 for ). There were no significant differences in the expressions of the , , , , , , and genes between the groups. : Decreased expressions of the , and genes were found in patients with RIF with thin endometria compared to the endometria of women with RPL. This has practical significance for clinicians for the differentiated prescription of immunomodulatory therapy in patients undergoing ART programs.
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| http://dx.doi.org/10.3390/jcm13206184 | DOI Listing |
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- A study involving 150 patients tested the effects of intrauterine perfusion of granulocyte colony-stimulating factor (G-CSF) and human chorionic gonadotropin (HCG) on pregnancy outcomes, comparing results among three groups (control, HCG, and G-CSF).
- The G-CSF group showed significant improvements in endometrial thickness, blood flow, and Treg levels, resulting in higher pregnancy rates than both the HCG and control groups, indicating G-CSF's potential benefit for patients with thin endometrium.
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