AI Article Synopsis
- - The study examined how MitoQ affects the in vitro maturation (IVM) of bovine oocytes and their embryonic development, finding that MitoQ increased both IVM rates and blastocyst success rates at low concentrations (1 and 5 µmol/L).
- - MitoQ treatment reduced reactive oxygen species (ROS) levels and improved mitochondrial functions by increasing GSH, MMP, ATP, and mt-DNA levels compared to the control group.
- - Additionally, MitoQ altered the expression of important proteins, decreasing BAX and increasing BCL2, DNM1, Mfn2, SOD, and CAT, leading to enhanced mitochondrial activity and reduced oxidative stress in oocytes from cul
Article Abstract
The purpose of this study was to investigate the effects and mechanisms of MitoQ on the IVM of culled bovine oocytes and subsequent embryonic development. The results revealed that in comparison to the control group (0 µmol/L), the IVM rate ( < 0.05) and subsequent blastocyst rate ( < 0.05) of the low-concentration 1 and 5 µmol/L MitoQ treatment group were increased. The level of ROS ( < 0.05) in the MitoQ treatment group was decreased in comparison to the control group. Additionally, the level of GSH, MMP, ATP, and mt-DNA in the MitoQ treatment group was increased ( < 0.05) in comparison to the control group. The expression level of BAX was decreased ( < 0.05) in the MitoQ treatment group, and the BCL2, DNM1, Mfn2, SOD, and CAT were increased ( < 0.05). In conclusion, MitoQ improved mitochondrial dysfunction, increased mitochondrial activity during IVM, and reduced oxidative stress, resulting in increased IVM rates and subsequent embryonic development from culled cows.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503749 | PMC |
| http://dx.doi.org/10.3390/ani14202929 | DOI Listing |
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