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as a Model to Study Aging and Photoaging. | LitMetric

as a Model to Study Aging and Photoaging.

Biomolecules

Department of Medical Sciences, School of Medicine, Walailak University, Nakhon Si Thammarat 80161, Thailand.

Published: September 2024

AI Article Synopsis

  • - The text discusses how a specific model organism is useful for studying aging due to its short lifespan, defined genome, and effective genetic tools for research.
  • - It distinguishes between chronological aging, which is linked to gradual physiological decline influenced by genetic and environmental factors, particularly the insulin signaling pathway, and photoaging, which involves damage from UV exposure and oxidative stress.
  • - The review emphasizes the need for further research on the genetic mechanisms of photoaging, while outlining known genetic pathways in chronological aging, to improve our understanding and potentially develop therapies for healthy aging in humans.

Article Abstract

() has emerged as an outstanding model organism for investigating the aging process due to its shortened lifespan, well-defined genome, and accessibility of potent genetic tools. This review presents the current findings on chronological aging and photoaging in , exploring the elaborate molecular pathways that control these processes. The progression of chronological aging is characterized by a gradual deterioration of physiological functions and is influenced by an interaction of genetic and environmental factors, including the insulin/insulin-like signaling (IIS) pathway. In contrast, photoaging is characterized by increased oxidative stress, DNA damage, and activation of stress response pathways induced by UV exposure. Although the genetic mechanisms of chronological aging in have been characterized by extensive research, the pathways regulating photoaging are comparatively less well-studied. Here, we provide an overview of the current understanding of aging research, including the crucial genes and genetic pathways involved in the aging and photoaging processes of . Understanding the complex interactions between these factors will provide invaluable insights into the molecular mechanisms underlying chronological aging and photoaging and may lead to novel therapeutic approaches and further studies for promoting healthy aging in humans.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505728PMC
http://dx.doi.org/10.3390/biom14101235DOI Listing

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