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Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma.
Nat Immunol
November 2024
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Tertiary lymphoid structures (TLS) are associated with improved response in solid tumors treated with immune checkpoint blockade, but understanding of the prognostic and predictive value of TLS and the circumstances of their resolution is incomplete. Here we show that in hepatocellular carcinoma treated with neoadjuvant immunotherapy, high intratumoral TLS density at the time of surgery is associated with pathologic response and improved relapse-free survival. In areas of tumor regression, we identify a noncanonical involuted morphology of TLS marked by dispersion of the B cell follicle, persistence of a T cell zone enriched for T cell-mature dendritic cell interactions and increased expression of T cell memory markers.
View Article and Find Full Text PDFInvoluted TLS as a harbinger of HCC regression.
Nat Immunol
November 2024
Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade.
bioRxiv
October 2023
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Article Synopsis
- Neoadjuvant immunotherapy may help achieve long-term tumor remission by boosting the body's immune responses before tumor removal, and this study explores the role of tertiary lymphoid structures (TLS) in this process for liver cancer (HCC).
- The research found that neoadjuvant immunotherapy not only promotes the formation of TLS but also correlates with better treatment outcomes, including higher levels of T and B cells and improved disease-free survival.
- Notably, the study observed that as tumors regress, TLS undergo changes that indicate continued immune activity and contribute to T cell memory, which may be crucial for long-term immunity against cancer.
The use of alpha 1 thymosin as an immunomodulator of the response against SARS-Cov2.
Immun Ageing
July 2023
Immunology Section, Laboratorio Inmuno-Biología Molecular (LIBM), Hospital General Universitario Gregorio Marañón (HGUGM), Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), 28009, Madrid, Spain.
Background: Since the beginning of SARS-CoV2 pandemic, the mortality rate among elderly patients (60-90 years) has been around 50%, so age has been a determining factor of a worse COVID-19 prognosis. Associated with age, the thymic function involution and depletion plays an important role, that could be related to a dysregulated and ineffective innate and adaptive immune response against SARS-CoV2. Our study aims to further in vitro effect of human Thymosin-alpha-1 (α1Thy) treatment on the immune system in population groups with different thymic function levels in the scenario of SARS-CoV2 infection.
View Article and Find Full Text PDFTumor lysis syndrome after propranolol therapy in ulcerative infantile hemangioma: rare complication or incidental finding?
Dermatology
October 2012
U.O. Dermatologia Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Milano, Italy.
A 33-day-old female with an ulcerated infantile hemangioma (IH) undergoing oral therapy with propranolol 2 mg/kg per day developed hyperkalemia and hyperphosphatemia 24 h after starting medication. No electrocardiographic or clinical abnormalities secondary to the electrolyte changes were noticed. A laboratory tumor lysis syndrome (TLS) was diagnosed after excluding other causes of electrolyte imbalance in the diagnostic workup.
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