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The self-organized structure of glioma oncostreams and the disruptive role of passive cells. | LitMetric

The self-organized structure of glioma oncostreams and the disruptive role of passive cells.

Sci Rep

Laboratory of Theoretical Physics and Modelling, CY Cergy-Paris Université, CNRS, 95032, Cergy-Pontoise, France.

Published: October 2024

AI Article Synopsis

Article Abstract

Oncostreams are self-organized structures formed by spindle-like, elongated, self-propelled cells recently described in glioblastomas and especially in gliosarcomas. Cells within these structures either move as large clusters in one main direction, flocks, or as linear, intermingling collections of cells advancing in opposite directions, streams. Round, passive cells are also observed, either inside or segregated from the oncostreams. Here we generalize a recently formulated particle-field approach to investigate the genesis and evolution of these structures, first showing that, in systems consisting only of identical self-propelled cells, both flocks and streams emerge as self-organized dynamic configurations. Flocks are the more stable configurations, while streams are transient and usually originate in collisions between flocks. Stream degradation is easier at low self-propulsion speeds. In systems consisting of both motile and passive cells, the latter block stream formation and accelerate their degradation and flock stabilization. Since the flock appears to be the most effective invasive structure, we thus argue that a phenotype mixture (motile and passive cells) may favor glioblastoma invasion. hlBy relating cellular properties to the observed outcome, our model shows that oncostreams are self-organized structures that result from the interplay between speed, shape, and steric repulsion.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11511870PMC
http://dx.doi.org/10.1038/s41598-024-74823-5DOI Listing

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