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The Prevalence and the Underlying Mechanisms of Fosfomycin Resistance of and spp. Among Cattle in Japan.
Int J Mol Sci
December 2024
Veterinary AMR Center, National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Tokyo 185-8511, Japan.
To investigate fosfomycin resistance rates in cattle across Japan, we carried out susceptibility tests. To identify the genes contributing to fosfomycin resistance, we performed whole-genome sequencing on the fosfomycin-resistant strains. were sampled from healthy cattle ( = 292, combined total from 2017, 2020, 2021, and 2022) and diseased cattle ( = 73, from 2021 to 2022).
View Article and Find Full Text PDFEfficacy of fosfomycin-containing regimens in treating severe infections caused by KPC-producing klebsiella pneumoniae and carbapenem-resistant acinetobacter baumannii in critically ill patients.
Int J Antimicrob Agents
December 2024
Department of Public Health and Infectious Diseases, Sapienza University of Rome; Fondazione Eleonora Lorillard Spencer Cenci, Rome, Italy.
Background: Fosfomycin (FOS) is gaining increasing importance as part of combination therapy for the treatment of carbapenem-resistant Acinetobacter baumannii (CRAB) and KPC-producing Klebsiella pneumoniae (KPC-Kp), thanks to its in vitro synergism with several antibiotics, high tissue distribution and good tolerability. We analyzed the effect on 30-day survival of FOS-containing regimens compared to non-FOS-containing regimens in critically ill patients admitted to the intensive care unit with CRAB or KPC-Kp infections. Secondary objectives were to evaluate clinical cure and microbiologic eradication in the FOS vs.
View Article and Find Full Text PDFA contribution on the fosfomycin mechanism of resistance in multidrug-resistant organisms.
Int J Antimicrob Agents
December 2024
Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
A Case of Catheter-Associated Urinary Tract Infection by Pseudomonas mendocina in the Setting of COVID-19.
Cureus
September 2024
Department of Internal Medicine, Mercy General Hospital, Sacramento, USA.
Article Synopsis
- A 70-year-old male with obstructive uropathy developed a catheter-associated urinary tract infection (CAUTI) caused by the rare bacteria Pseudomonas mendocina after testing positive for COVID-19.
- Urine cultures revealed both P. mendocina and Enterococcus faecalis, prompting an antibiotic regimen change that initially improved the patient's condition, but he was readmitted later for recurring symptoms and complications.
- The case emphasizes the potential link between COVID-19 and increased bacterial infections in patients with pre-existing conditions, highlighting the need for more research on this interaction and careful clinical management.
Whole-genome sequencing of Klebsiella pneumoniae MDR circulating in a pediatric hospital setting: a comprehensive genome analysis of isolates from Guayaquil, Ecuador.
BMC Genomics
October 2024
Human Genomics Corporation S.A.S., Loja, Ecuador.
Background: Klebsiella pneumoniae is the major cause of nosocomial infections worldwide and is related to a worsening increase in Multidrug-Resistant Bacteria (MDR) and virulence genes that seriously affect immunosuppressed patients, long-stay intensive care patients, elderly individuals, and children. Whole-Genome Sequencing (WGS) has resulted in a useful strategy for characterizing the genomic components of clinically important bacteria, such as K. pneumoniae, enabling them to monitor genetic changes and understand transmission, highlighting the risk of dissemination of resistance and virulence associated genes in hospitals.
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