Introduction: Ectopic thyroid tissue (ETT) occurs due to abnormal embryogenesis of the thyroid gland. Ectopic thyroid tissue is susceptible to all the processes that affect normal thyroid tissue, including malignant transformation. Malignancy of ectopic thyroid tissue is known as the exceedingly rare phenomenon of ectopic thyroid carcinoma (ETC).
Presentation Of Case: A 97-year old female presented with an ulcerated, hemorrhagic lateral neck mass that had been present for years prior to her visit. The mass was initially misdiagnosed as a haemangioma. During the surgical procedure, the operating surgeons discovered hallmark signs pointing towards malignancy. Histopathology of a biopsy taken from the mass confirmed the diagnosis of ectopic thyroid carcinoma (ETC). The patient was discharged in good condition and did not require further intervention.
Discussion: The presence of ectopic thyroid carcinoma in the lateral neck is an extremely scarce finding. Medical literature details multiple modalities of diagnosis. We discuss similar cases and provide a comparison of currently applied diagnostic and therapeutic measures.
Conclusion: Thus far, no consensus has been reached regarding the optimal treatment or diagnosis of ectopic thyroid cancer, mainly due to their scarcity within the literature. As with most malignancies, early diagnosis is of great importance in order to ensure better outcomes. Individualised treatment options remain the cornerstone of the treatment of ETCs. More research is needed to outline practical tests to calibrate treatment in future cases.
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http://dx.doi.org/10.1016/j.ijscr.2024.110496 | DOI Listing |
J Clin Endocrinol Metab
January 2025
IMAGINE Institute Affiliate, INSERM U1163, Paris, France.
Context: Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder and is chiefly caused by thyroid dysgenesis (CHTD). The inheritance mode of the disease remains complex.
Objectives: Gain insight into the inheritance mode of CHTD.
J Clin Endocrinol Metab
January 2025
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Palle-Juul Jensens Boulevard 165, 8200 Aarhus N, Denmark.
Context: Few studies have reported on males with 45,X/46,XY mosaicism. Most studies stem from pediatric settings and knowledge of natural history and long-term health outcomes are therefore lacking.
Objective: To describe long-term health outcomes in males with 45,X/46,XY in comparison to the general population.
Nutrients
December 2024
Department of Food Science and Nutrition, Dankook University, Cheonan 31116, Republic of Korea.
Background/objectives: Functional probiotics, particularly subsp. CKDB001, have shown potential as a therapeutic option for metabolic dysfunction-associated steatotic liver disease (MASLD). However, their effects have not been confirmed in in vivo systems.
View Article and Find Full Text PDFJ Clin Med
December 2024
Nuclear Medicine, ASST Spedali Civili di Brescia and Università Degli Studi di Brescia, 25123 Brescia, Italy.
: Struma ovarii (SO) is an ovarian teratoma with the presence of ectopic thyroid tissue. Differentiated thyroid cancer (DTC) in SO is a rare finding. Management of DTC in SO is currently not clearly established.
View Article and Find Full Text PDFFront Pediatr
December 2024
Department of Neonatology, Khoo Teck Puat-National University Children Medical Institute, National University Health System, Singapore, Singapore.
Background: Vinblastine is a widely used chemotherapeutic agent for various cancers. We report a case of transient congenital hypothyroidism following maternal exposure to vinblastine during the third trimester of pregnancy and propose possible mechanisms of action.
Method: We utilized the CARE guidelines to report the case.
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