Experimental Investigations of Assessment of Acute Toxicity of Drilling Mud.

At present, the main technological stages of oil production related to drilling operations require the use of a wide variety of drilling mud, which has a complex, multicomponent chemical composition. The drilling mud used and the resulting drilling waste must be safe for human health and the environment. The toxicity and hazard of drilling mud at this point in time remain poorly understood scientific problems and require detailing and studying in toxicological terms. The real degree of hazard and toxicity of drilling mud can only be determined by an experimental method, since its composition, which changes depending on the nature of the technological process and its degree of depletion, is not constant, which can change the toxicological properties. In an experiment conducted on adult male rats, under conditions of a single intragastric injection of drilling mud, new data were obtained regarding the parameters of its toxicity and hazard. The use of a wide variety of methods for determining lethal doses of drilling mud, including the probit analysis method, made it possible not only to substantiate the mean lethal dose of drilling mud but also other parameters of toxicity and survival of animals in the experimental groups. Features of eating behavior and body weight dynamics and the nature of the behavioral reactions revealed by the number and duration of stands and frequency and duration of grooming also indicate the presence of dose-dependent effects.