AI Article Synopsis
- - Six new terpenoid compounds were discovered from a marine fungus, including three labdane-type diterpenes (talaroterpenoids A-C) and three meroterpenoids (talaroterpenoids D-F), along with five known compounds.
- - Their chemical structures were determined using various advanced techniques like NMR, high-resolution mass spectrometry, and crystallography.
- - Some of the new compounds demonstrated inhibitory effects on nitric oxide release in specific brain cells, while one showed moderate antifungal properties against certain fungi.
Article Abstract
Six new highly oxidized -terpenoids, including three 3--labdane type diterpenes, talaroterpenoids A-C (-), and three meroterpenoids containing an orthoester group, talaroterpenoids D-F (-), together with five known compounds (- and -), were isolated from the marine-derived fungus . Their chemical structures were elucidated through 1D, 2D NMR, HRESIMS, -based configuration analysis (JBCA), computational ECD calculations, and single-crystal X-ray diffraction analysis. Compounds and contain an unusual 6,20--lactone-bridged scaffold. Compounds and presented inhibitory effects on NO release in lipopolysaccharide (LPS)-induced BV-2 cells with IC values of 11.47 and 11.32 μM, respectively. Talaroterpenoid C () showed moderate antifungal activity against and Steyaert.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11509394 | PMC |
| http://dx.doi.org/10.3390/md22100475 | DOI Listing |
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