AI Article Synopsis

  • A retrospective study assessed the diagnostic effectiveness of C-reactive protein (CRP) and leucocyte count in differentiating complicated (CAA) from uncomplicated acute appendicitis (UAA) based on EAES guidelines, involving 285 patients in Germany from 2019 to 2021.
  • The study found that CRP levels were significantly higher in CAA patients compared to UAA patients, showing medium diagnostic value for identifying CAA and a cutoff at 44.3 mg/L, while leucocyte count had a low predictive value.
  • Higher CRP levels were linked to an increased risk of postoperative complications and longer hospital stays, indicating that CRP is a useful marker for diagnosing CAA within the EA

Article Abstract

: In this retrospective study, we evaluate the diagnostic utility of C-reactive protein (CRP) and leucocyte count within the EAES 2015 guidelines for acute appendicitis (AA) in differentiating uncomplicated (UAA) from complicated AA (CAA). Conducted at a tertiary care center in Germany, the study included 285 patients over 18 years who were diagnosed with AA from January 2019 to December 2021. Patient data included demographics, inflammatory markers, and postoperative outcomes. CRP levels (Md: 60.2 mg/dL vs. 10.5 mg/dL; < 0.001) and leucocyte count (Md: 14.4 Gpt/L vs. 13.1 Gpt/L; = 0.016) were higher in CAA. CRP had a medium diagnostic value for detecting CAA (AUC = 0.79), with a cutoff at 44.3 mg/L, making it more likely to develop CAA. Leucocyte count showed low predictive value for CAA (AUC = 0.59). CRP ≥ 44.3 mg/L was associated with a higher risk of postoperative complications (OR: 2.9; = 0.002) and prolonged hospitalization (OR: 3.5; < 0.001). CRP, within the context of the EAES classification, presents as a valuable diagnostic marker to distinguish CAA from UAA, with a higher risk of postoperative complications and hospitalization. Leucocyte count showed low diagnostic value for the identification of CAA.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11506629PMC
http://dx.doi.org/10.3390/diagnostics14202335DOI Listing

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