AI Article Synopsis
- This study assesses how choroidal blood flow (CBF) and choroidal thickness (CT) can predict if macular edema will return in patients with a specific type of eye condition (BRVO) after receiving treatment.
- Sixteen patients were treated with an injection and monitored for changes in CBF and CT over a year using specialized imaging techniques.
- Results showed that thicker CT in affected areas initially dropped after one week, while CBF remained steady; however, an imbalance in CBF was linked to how many injections were later needed, suggesting it could help predict recurrence of macular edema.
Article Abstract
Background/objectives: To evaluate the roles of choroidal blood flow (CBF) and choroidal thickness (CT) as predictors of macular edema recurrence in patients with treatment-naive non-ischemic branch retinal vein occlusion (BRVO) after intravitreal ranibizumab (IVR) injection.
Methods: Sixteen eyes from sixteen patients with treatment-naive non-ischemic BRVO treated with IVR, once initially and then as needed, were included in the study. CBF and CT in the subfovea, occlusive, and non-occlusive regions were measured via laser speckle flowgraphy and enhanced depth imaging optical coherence tomography over 12 months.
Results: Baseline CT was significantly greater in the occlusive region (335 ± 72.1 µm) than in the non-occlusive region (274 ± 36.7 µm, = 0.028). CT in the occlusive region was reduced significantly after 1 week ( = 0.008), but CBF did not change significantly after IVR throughout the follow-up period ( > 0.05). The occlusive/non-occlusive region CBF ratio at baseline was significantly associated with the number of IVR injections over 12 months (mean 2.63) in patients with BRVO ( = 0.048).
Conclusions: Baseline CBF imbalance in eyes with treatment-naive BRVO may indicate the recurrence of macular edema after ranibizumab therapy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507006 | PMC |
| http://dx.doi.org/10.3390/diagnostics14202328 | DOI Listing |
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