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Acute Myocardial Infarction Due to Metastatic Melanoma Tumor Embolization.
JACC Case Rep
December 2024
Division of Cardiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Embolic myocardial infarction (MI) due to malignancy is a rare clinical entity defined by embolization of cancerous tissue to the coronary arteries. We present the case of a 49-year-old man presenting with an anterolateral MI in the setting of metastatic melanoma tumor embolization.
View Article and Find Full Text PDFInducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis.
J Clin Invest
October 2024
Division of Thoracic Surgery/Canning Thoracic Institute, Feinberg School of Medicine, Northwestern University/Northwestern Medicine, Chicago, Illinois, USA.
A major limitation of immunotherapy is the development of resistance resulting from cancer-mediated inhibition of host lymphocytes. Cancer cells release CCL2 to recruit classical monocytes expressing its receptor CCR2 for the promotion of metastasis and resistance to immunosurveillance. In the circulation, some CCR2-expressing classical monocytes lose CCR2 and differentiate into intravascular nonclassical monocytes that have anticancer properties but are unable to access extravascular tumor sites.
View Article and Find Full Text PDFIntravascular Melanoma Metastasis Detected During Mohs Micrographic Surgery for Invasive Melanoma.
Dermatol Surg
October 2024
Mohs and Skin Surgery Center, Skin Care Specialty Physicians, Lutherville, MD.
Platelet Angiopoietin-1 Protects Against Murine Models of Tumor Metastasis.
Arterioscler Thromb Vasc Biol
September 2024
Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA (H.G.R., M.W.M., E.M.C., S.A.M., P.L.K., E.M.B.).
Background: In addition to their fundamental roles in preserving vascular integrity, platelets also contribute to tumor angiogenesis and metastasis. However, despite being a reservoir for angiogenic and metastatic cytokines, platelets also harbor negative regulators of tumor progression. Angpt1 (angiopoietin-1) is a cytokine essential for developmental angiogenesis that also protects against tumor cell metastasis through an undefined mechanism.
View Article and Find Full Text PDFSystemic capillary leak syndrome in a patient treated with nivolumab/ipilimumab immunotherapy for metastatic melanoma with concurrent COVID-19 vaccination.
BMJ Case Rep
July 2024
The University of Sydney Nepean Clinical School, Kingswood, New South Wales, Australia
Systemic capillary leak syndrome (SCLS) is a rare and life-threatening disorder characterised by leaking of intravascular fluid to extravascular tissues. An association with immunotherapy and COVID-19 vaccination has been reported as potential triggers. A case of a patient in her 70s developing SCLS after the BNT162b2 (Pfizer-BioNTech) COVID-19 vaccination with a history of metastatic melanoma treated with nivolumab (PD-1 monoclonal antibody) and ipilimumab (anti-CTLA4 monoclonal antibody) is reported.
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