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Gall Stone Ileus and Recurrence: Management Dilemma for the Operating Surgeon.
Cureus
December 2024
Department of Surgery, Royal Oldham Hospital, Northern Care Alliance NHS Trust, Manchester, GBR.
Gallstone ileus (GSI) is a rare complication of gallstone disease. It occurs as a result of the passage of a stone from the biliary tract into the gastrointestinal tract via an abnormal pathway (bilio-enteric fistula). Chronic inflammatory processes result in gall bladder adhering and subsequently eroding into the intestines, leading to a fistula.
View Article and Find Full Text PDFLatent bladder hypersensitivity induced by neonatal cystitis in rats unmasked by segmental but not hetero-segmental inflammation.
Neurosci Lett
January 2025
Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Rats which experienced neonatal bladder inflammation (NBI) have been demonstrated to exhibit latent bladder hypersensitivity with a nociceptive component that becomes unmasked by a second inflammatory insult as an adult. Manifested as augmented reflex and neuronal responses to urinary bladder distension (UBD), these NBI-induced changes are revealed by using inflammation of nearby structures as an adult pretreatment. The effect of inflammation in distant structures is not known.
View Article and Find Full Text PDFExpression of Acid-Sensing Ion Channel 3 in Afferents Averts Long-Term Sensitization and the Development of Visceral Pain.
Int J Mol Sci
November 2024
Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburg, PA 15261, USA.
Sensitization of primary afferents is essential for the development of pain, but the molecular events involved in this process and its reversal are poorly defined. Recent studies revealed that acid-sensing ion channels (ASICs) control the excitability of nociceptors in the urinary bladder. Using genetic and pharmacological tools we show that ASICs are functionally coupled with voltage-gated Ca channels to mediate Ca transients evoked by acidification in sensory neurons.
View Article and Find Full Text PDFA potential therapeutic strategy using a miniature, implantable, wireless nerve stimulation device for treating stress urinary incontinence in rats.
Int Urol Nephrol
December 2024
Department of Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Purpose: The present study examined the effects of a miniature, implantable, wireless stimulation device for treating stress urinary incontinence (SUI) in rats.
Methods: Twenty-four female Sprague-Dawley rats were randomly assigned to three groups: Group 1 (Control), Group 2 (Sham), and Group 3 (Stimulation). All animals underwent vaginal distension (VD) to mimic postpartum SUI.
MRI-guided brachytherapy for cervical cancer treatment: The significance of bladder morphology in dose distribution planning.
J Contemp Brachytherapy
June 2024
Department of Radiation Oncology, Keimyung University, Dongsan Hospital, Dalgubeol-daero, Daegu, South Korea.
Purpose: This retrospective study aimed to investigate the influence of bladder filling type (BFT) on the relationship between bladder volume (BV) and maximum absorbed dose (D) in intra-cavitary brachytherapy (ICBT) for cervical cancer.
Material And Methods: The study enrolled 269 patients who underwent 3D-optimized ICBT guided by MRI scans between 2016 and 2022. Bladder shape (categorized as tilted, curved, or E) was determined based on specific applicators used.
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