Epigenetic inheritance is hypothesized to lead to rapid adaptation, yet evidence is scarce, possibly because of the current experimental approaches. We propose a new approach to simultaneously assess whether species adapt through selection of epimutations or formation of stress‐induced epialleles.
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http://dx.doi.org/10.1111/pce.15220 | DOI Listing |
Melanoma is an aggressive type of skin cancer that arises from melanocytes, the cells responsible for producing skin pigment. In contrast to non-melanoma skin cancers like basal cell carcinoma and squamous cell carcinoma, melanoma is more invasive. Melanoma was distinguished by its rapid progression, high metastatic potential, and significant resistance to conventional therapies.
View Article and Find Full Text PDFJ Clin Transl Sci
December 2024
Vanderbilt Institute for Clinical and Translational Research, University Medical Center, Nashville, TN, USA.
There is a growing trend for studies run by academic and nonprofit organizations to have regulatory submission requirements. As a result, there is greater reliance on REDCap, an electronic data capture (EDC) widely used by researchers in these organizations. This paper discusses the development and implementation of the Rapid Validation Process (RVP) developed by the REDCap Consortium, aimed at enhancing regulatory compliance and operational efficiency in response to the dynamic demands of modern clinical research.
View Article and Find Full Text PDFNatl Sci Rev
February 2025
State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
In the evolving landscape of materials science, the journey from traditional composite materials to liquid-solid composites has marked a significant shift. Composite materials, typically solid state, have long been the cornerstone of many applications due to their structural stability and mechanical properties. However, the emergence of liquid-solid composites has introduced a new paradigm, leveraging the dynamic composite interfaces and fluidic nature of liquids.
View Article and Find Full Text PDFVirus Evol
December 2024
Department of Microbiology and Immunology, McGill University, 3775 University Street Montreal, QC H3A 2B4, Canada.
Infectious disease transmission to different host species makes eradication very challenging and expands the diversity of evolutionary trajectories taken by the pathogen. Since the beginning of the ongoing COVID-19 pandemic, SARS-CoV-2 has been transmitted from humans to many different animal species, in which viral variants of concern could potentially evolve. Previously, using available whole genome consensus sequences of SARS-CoV-2 from four commonly sampled animals (mink, deer, cat, and dog), we inferred similar numbers of transmission events from humans to each animal species.
View Article and Find Full Text PDFTandem duplication of genes can play a critical role in the evolution of functional novelty, but our understanding is limited concerning gene duplication's role in coevolution between species. Much is known about the evolution and function of tandemly duplicated snake venom genes, however the potential of gene duplication to fuel venom resistance within prey species is poorly understood. In this study, we characterize patterns of gene duplication of the SERPINA subfamily of genes across in vertebrates and experimentally characterize functional variation in the SERPINA3-like paralogs of a wild rodent.
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