AI Article Synopsis
- Cancer is the leading cause of death, with over 50% of patients undergoing radiotherapy, which can lead to radiation-induced skin reactions (RISR) that significantly affect their quality of life.
- The review highlights that oxidative stress (OS) is believed to be a key initial factor in the development of various types of RISRs and discusses the underlying mechanisms involved.
- While traditional treatments for RISRs have shown limited success, the review suggests further research into novel therapeutic strategies aimed at managing oxidative stress and improving outcomes for patients.
Article Abstract
According to official statistics, cancer remains the main reason of death and over 50% of patients with cancer receive radiotherapy. However, adverse consequences after radiation exposure like radiation-induced skin reactions (RISR) have negative or even fatal impact on patients' quality of life (QoL). In this review we summarize the mechanisms and managements of RISRs, a process that involve a variety of extracellular and intracellular signals, among which oxidative stress (OS) are now commonly believed to be the initial part of the occurrence of all types of RISRs. As for the management of RISRs, traditional treatments have been widely used but without satisfying outcomes while some promising therapeutic strategies related to OS still need further researches. In the context we discuss how OS leads to the happening of RISRs of different types, hoping it can shed some light on the exploration of new countermeasures.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500330 | PMC |
| http://dx.doi.org/10.3389/fcell.2024.1480571 | DOI Listing |
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