Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500313 | PMC |
| http://dx.doi.org/10.1017/ash.2024.440 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dr. SB Wey: a path of influence and discovery in hospital epidemiology.
Antimicrob Steward Healthc Epidemiol
October 2024
Hospital Israelita Albert Einstein, São Paulo, Brazil.
Probabilistic pathway-based multimodal factor analysis.
Bioinformatics
June 2024
Biomedical Informatics Group, Department of Computer Science, ETH Zurich, 8092 Zurich, Switzerland.
Motivation: Multimodal profiling strategies promise to produce more informative insights into biomedical cohorts via the integration of the information each modality contributes. To perform this integration, however, the development of novel analytical strategies is needed. Multimodal profiling strategies often come at the expense of lower sample numbers, which can challenge methods to uncover shared signals across a cohort.
View Article and Find Full Text PDFInvestigation of reactive astrogliosis effect on post-stroke cognitive impairment.
J Neuroinflammation
October 2020
Department of Nuclear Medicine and Molecular Imaging Center, Linkou Chang Gung Memorial Hospital, No. 5, Fuxing St., Guishan, Taoyuan, Taiwan.
Article Synopsis
- - The study aimed to explore how the severity of cognitive impairment after a stroke (PSCI) relates to the extent of reactive astrogliosis (RA) as observed through F-THK-5351 PET imaging in amyloid-negative patients who experienced their first stroke.
- - Researchers examined 63 patients about 3 months post-stroke, using various imaging and cognitive assessments to evaluate the relationship between RA (measured as Z-SUM scores) and cognitive function, adjusting for other health variables.
- - Results indicated that patients with PSCI were typically older, less educated, and exhibited greater brain atrophy. The analysis showed significant associations between Z-SUM scores and cognitive functions, suggesting that RA plays a role in the severity of
Five-tier utility: A start on the path to better reporting, in response to Schold and Buccini.
Am J Transplant
February 2019
Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN, USA.
PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat.
ACS Chem Neurosci
October 2014
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Histone deacetylase (HDAC) enzymes have been demonstrated as critical components in maintaining chromatin homeostasis, CNS development, and normal brain function. Evidence in mouse models links HDAC expression to learning, memory, and mood-related behaviors; small molecule HDAC inhibitor tool compounds have been used to demonstrate the importance of specific HDAC subtypes in modulating CNS-disease-related behaviors in rodents. So far, no direct evidence exists to understand the quantitative changes in HDAC target engagement that are necessary to alter biochemistry and behavior in a living animal.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!