AI Article Synopsis
- * The condition can affect various mucosal areas, including the mouth and genitals, and is typically triggered by a hypersensitivity reaction to drugs like NSAIDs, antibiotics, and anticonvulsants.
- * A case study is presented of a 79-year-old woman who developed TEN after taking clindamycin for a sacral ulcer, emphasizing the need for awareness and quick management of SJS/TEN after new medication use to enhance patient outcomes.
Article Abstract
Toxic epidermal necrolysis (TEN) is a rare, acute inflammatory skin reaction that results in skin blistering and extensive epidermal detachment. Stevens-Johnson syndrome (SJS) and TEN are unified aspects on a spectrum varying in the severity of vesiculobullous cutaneous eruptions with mucosal involvement of the oral cavity, genitourinary tract, gastrointestinal tract, and conjunctiva. The inciting event is usually caused by an exaggerated hypersensitivity reaction in response to triggering medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics, urate-lowering drugs (such as allopurinol), anticonvulsants, and antipsychotics. We report a case of clindamycin-induced TEN in a 79-year-old African-American female following the recent administration of clindamycin for a developing sacral decubitus ulcer. However, lincosamide antibiotics like clindamycin are rarely associated with precipitating SJS or TEN. This report highlights the treatment and prognostic challenges faced throughout the patient's clinical course and seeks to highlight the importance of recognizing the development of SJS/TEN following novel drug administration and promptly addressing the management of the condition to improve long-term patient outcomes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500725 | PMC |
| http://dx.doi.org/10.7759/cureus.70098 | DOI Listing |
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