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Employing a PhI(OAc)-mediated domino reaction to assemble nitrogen-containing heterocyclic derivatives and assessing their anti-inflammatory activity. | LitMetric
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Employing a PhI(OAc)-mediated domino reaction to assemble nitrogen-containing heterocyclic derivatives and assessing their anti-inflammatory activity.

Xinyue Li Yuhua Fang Yuanyuan Zhao Shenshen Luo Yuhui Xue Tingting Yong Bin Wang

Chem Commun (Camb)

College of Chinese Medicine, the First Affiliated Hospital, and Key Laboratory of Xin'an Medicine of the Ministry of Education, Anhui University of Chinese Medicine, Hefei, 230038, P. R. China.

Published: November 2024

Metal-free radical cascade synthesis of substituted pyrazole derivatives was initiated by PhI(OAc) at 23 °C. This protocol features wide functional group tolerance, a simple purification process without column chromatography, and an oxygen migration. Compound 5 demonstrated significant anti-inflammatory activity, indicating potential for therapy.

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 Source
http://dx.doi.org/10.1039/d4cc03245dDOI Listing

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