AI Article Synopsis

  • * The program has screened over 7,500 infants since September 2020, identifying 126 with SCD and 1,546 with sickle cell trait (SCT), with a significant percentage receiving genetic counseling and timely referrals for further care.
  • * This initiative demonstrates that a sustainable SCD screening and counseling program can be effectively implemented even in low-income settings, improving outcomes for affected newborns and their families.

Article Abstract

Newborn screening for sickle cell disease (SCD) is sparse in sub-Saharan Africa. The leadership of the Aminu Kano Teaching Hospital (AKTH) in Kano, Nigeria, with the support of local religious authorities, established a groundbreaking SCD newborn screening program that has become the standard of care for pregnant women and their newborns. Our program includes (1) prenatal genetic counseling for all pregnant women in the antenatal clinic, (2) newborn screening, (3) postnatal genetic counseling for parents of newborns diagnosed with SCD and SCT, and (4) referral of newborns with SCD for follow-up in the SCD Comprehensive Care Clinic by 3 months of age. From September 2020 to December 2023, the team screened 7530 infants for SCD at the AKTH, identifying 126 (1.7%) infants with SCD and 1546 (20.5%) with SCT. Of these, 93 (73.8%) newborns with SCD received individualized genetic counseling, and 43 (46%) were referred to the SCD Comprehensive Care Clinic before 3 months. Group genetic counseling was provided to the parents of 778 (50.3%) of newborns identified with SCT. The SCD newborn screening at the AKTH is now standard care, indicating the viability of sustaining an SCD newborn screening program that provides pre- and postnatal genetic counseling and comprehensive SCD care within a low-income setting.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503303PMC
http://dx.doi.org/10.3390/ijns10040067DOI Listing

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