This paper introduces functional quantile principal component analysis (FQPCA), a dimensionality reduction technique that extends the concept of functional principal components analysis (FPCA) to the examination of participant-specific quantiles curves. Our approach borrows strength across participants to estimate patterns in quantiles, and uses participant-level data to estimate loadings on those patterns. As a result, FQPCA is able to capture shifts in the scale and distribution of data that affect participant-level quantile curves, and is also a robust methodology suitable for dealing with outliers, heteroscedastic data or skewed data. The need for such methodology is exemplified by physical activity data collected using wearable devices. Participants often differ in the timing and intensity of physical activity behaviors, and capturing information beyond the participant-level expected value curves produced by FPCA is necessary for a robust quantification of diurnal patterns of activity. We illustrate our methods using accelerometer data from the National Health and Nutrition Examination Survey, and produce participant-level 10%, 50%, and 90% quantile curves over 24 h of activity. The proposed methodology is supported by simulation results, and is available as an R package.
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http://dx.doi.org/10.1093/biostatistics/kxae040 | DOI Listing |
Toxics
January 2025
Department of Environmental and Occupational Health, Guangxi Medical University, Nanning 530021, China.
Background: While current epidemiological studies have documented associations between environmental metals and renal dysfunction, the majority have concentrated on plasma metal levels. The relationship between urinary metal exposure and chronic kidney disease (CKD) remains contentious, particularly within specific demographic groups.
Methods: This cross-sectional study included 2919 rural Chinese adults recruited between 2018 and 2019.
Elife
January 2025
Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Apart from ancestry, personal or environmental covariates may contribute to differences in polygenic score (PGS) performance. We analyzed the effects of covariate stratification and interaction on body mass index (BMI) PGS (PGS) across four cohorts of European (N = 491,111) and African (N = 21,612) ancestry. Stratifying on binary covariates and quintiles for continuous covariates, 18/62 covariates had significant and replicable R differences among strata.
View Article and Find Full Text PDFEnviron Int
January 2025
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032 Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032,Anhui, China; Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, No 81 Meishan Road, Hefei 230032 Anhui, China. Electronic address:
Introduction: Prenatal exposure to organophosphate esters (OPEs) and phthalic acid esters (PAEs) is ubiquitous among pregnant individuals. However, research exploring the relationship between prenatal co-exposure to OPEs and PAEs and childhood insulin function remains limited.
Methods: In this study, utilizing data from 2,246 maternal-fetal dyads in the Ma'anshan Birth Cohort, associations between co-exposure to OPEs and PAEs and insulin action were analyzed.
Ecotoxicol Environ Saf
January 2025
Department of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China. Electronic address:
Background: Exposure to brominated flame retardants (BFRs) may negatively impact human health. The association of BFRs with nonalcoholic fatty liver disease (NAFLD) in the general population is unclear. Meanwhile, limited studies have investigated the potential role of oxidative stress and inflammation in this link.
View Article and Find Full Text PDFAnn Emerg Med
January 2025
Emergency and Trauma Center, Royal Brisbane and Women's Hospital, Brisbane, Australia.
Study Objectives: Concentrated albumin early in sepsis resuscitation remains largely unexplored. Objectives were to determine 1) feasibility of early intervention with concentrated albumin in emergency department (ED) patients with suspected infection and hypoperfusion and 2) whether early albumin therapy improves outcomes.
Methods: ED patients with suspected infection and hypoperfusion (systolic blood pressure [SBP]<90 mmHg or lactate ≥4.
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