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Neurophysiological assessment of cortical motor function: A direct comparison of methodologies.
Clin Neurophysiol
December 2024
Neuroscience Research Australia, 139 Barker Street, Randwick, 2031, Sydney, Australia; University of NSW and Department of Neurology, Prince of Wales Hospital, South Eastern Sydney Area Health Service, Sydney, Australia.
Objective: Assessment of cortical function with threshold tracking transcranial magnetic stimulation (TT-TMS) has developed as a biomarker to inform disease pathophysiology, particularly in neurodegenerative disease and dementia. At present, a fully integrated testing system does not exist. To advance clinical utility, and to streamline software design to integrate with diagnostic approaches in an outpatient setting, the present series of studies assessed the effects of altering diagnostic paradigms to measure interstimulus interval (ISI) including serial ascending [T-SICIs] and parallel [T-SICIp] methodologies as measures of cortical motor function (the MagXite software).
View Article and Find Full Text PDF"Instead of Building More Buildings, They Should Plant More Trees", a Photovoice Study of Determinants of Happiness and Sadness Among East London Adolescents.
Qual Health Res
November 2024
Unit for Social and Community Psychiatry, WHO Collaborating Centre, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Article Synopsis
- * The study utilized Photovoice, a community-based participatory method, to allow adolescents to express their experiences through photography and text, revealing how environmental factors significantly impact their happiness and sadness.
- * Findings highlight that a connection to nature enhances happiness, while concerns about urban development and pollution exacerbate mental health issues; this research not only captures the voices of a neglected demographic but also emphasizes the importance of participatory methods in adolescent mental health studies.
Response to Dr Dancer.
J Hosp Infect
November 2024
Department of Infection Prevention, UNC Medical Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Response to Kiernan et al.: is detergent-only cleaning paired with chlorine disinfection the best approach for cleaning?
J Hosp Infect
January 2025
NHS England, National Infection Prevention and Control Team, Nursing Directorate, Leeds, UK.
Direct interrogation of cortical interneuron circuits in amyotrophic lateral sclerosis.
Brain
October 2024
The Brain and Nerve Research Centre, Concord Clinical School, The University of Sydney, NSW, 2139, Australia.
Article Synopsis
- Cortical hyperexcitability in amyotrophic lateral sclerosis (ALS) is linked to complex interactions between cortical interneurons, with this study examining GABA-ergic dysfunction via a combination of transcranial magnetic stimulation (TMS) and EEG.
- In 21 ALS patients, TMS-EEG results showed significant differences in the transcranial evoked potential (TEP) components compared to healthy controls, indicating impaired cortical inhibitory function.
- Notably, changes in TEP components correlated with muscle weakness and longer disease duration, highlighting the role of disrupted GABA-ergic circuits in the progression of ALS.
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