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The immune landscape of the inflamed joint defined by spectral flow cytometry.
Clin Exp Immunol
November 2024
Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK.
Cellular phenotype and function are altered in different microenvironments. For targeted therapies it is important to understand site-specific cellular adaptations. Juvenile idiopathic arthritis (JIA) is characterized by autoimmune joint inflammation, with frequent inadequate treatment responses.
View Article and Find Full Text PDFIntegration of Genetic and Clinical Risk Factors for Risk Classification of Uveitis in Patients With Juvenile Idiopathic Arthritis.
Arthritis Rheumatol
December 2024
NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, UK.
Objective: Juvenile idiopathic arthritis (JIA)-associated uveitis (JIAU) is a serious JIA comorbidity that can result in vision impairment. This study aimed to identify genetic risk factors within the major histocompatibility complex for JIAU and evaluate their contribution for improving risk classification when combined with clinical risk factors.
Methods: Data on single nucleotide polymorphisms, amino acids, and classical HLA alleles were available for 2,497 patients with JIA without uveitis and 579 patients with JIAU (female 2,060, male 1,015).
Reflections on the CODES trial for adults with dissociative seizures: what we found and considerations for future studies.
BMJ Neurol Open
June 2024
Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
The COgnitive behavioural therapy versus standardised medical care for adults with Dissociative non-Epileptic Seizures multicentre randomised controlled trial is the largest, fully-powered study to test the clinical and cost-effectiveness of a psychotherapeutic intervention in this population. We also explored predictors or moderators of outcomes and investigated mechanisms of change in therapy. In this current review of findings, we discuss issues related to the design of the trial and consider the study's nested qualitative studies which were undertaken not only to shed light on the original research questions but to provide insights and recommendations for other researchers in the field of functional neurological disorder.
View Article and Find Full Text PDFImprovement of the Upper Detection Limit of Ionophore-Based H-Selective Electrodes: Explanation and Elimination of Apparently Super-Nernstian Responses.
Anal Chem
June 2024
Department of Chemistry, University of Minnesota, 207 Pleasant Street, Minneapolis, Minnesota 55455, United States.
The response range of an ion-selective electrode (ISE) has been described by counterion interference at the lower and Donnan failure at the upper detection limit. This approach fails when the potentiometric response at the upper detection limit exhibits an apparently super-Nernstian response, as has been reported repeatedly for H-selective electrodes. While also observed when samples contain other anions, super-Nernstian responses at low pH are a problem in particular for samples that contain phthalate, a common component of commercial pH calibration solutions.
View Article and Find Full Text PDFHeavy Atom Quantum Mechanical Tunneling in Total Synthesis.
Org Lett
June 2024
Department of Chemistry, University of California - Davis, 1 Shields Ave, Davis, California 95616, United States.
Contributions from quantum mechanical tunneling to the rates of several radical coupling reactions between carbon sp centers used as key steps in natural product total syntheses were computed using density functional theory. Contributions ranging from ∼15-52% from tunneling were predicted at room temperature, thereby indicating that tunneling plays an important role in the rates of these reactions and should perhaps be considered when designing complex synthetic schemes.
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