In water, Ru-catalyzed annulation of -chlorobenzamides with unsymmetrical internal alkynes bearing aryl, hydroxy, ester, and sulfonyl functionalities has been accomplished to afford isoquinolone scaffolds under external oxidant-free conditions at room temperature. Use of water as reaction medium, redox-neutral conditions, regioselectivity, and substrate scope are important practical features.
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| http://dx.doi.org/10.1021/acs.joc.4c02234 | DOI Listing |
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