[Stage-dependent treatment of seminomas].

Urologie

Klinik für Urologie, Uro-Onkologie, spezielle urologische und Roboter-assistierte Chirurgie, Uniklinik Köln, Kerpenerstr. 62, 50937, Köln, Deutschland.

Published: December 2024

AI Article Synopsis

  • * Seminomas are sensitive to radiation, making it a treatment option for early stages, though there's caution due to potential increased risk of secondary cancers.
  • * For nonmetastasized stages, active surveillance is preferred to avoid unnecessary treatment, with nerve-sparing surgery considered in low metastasis cases; guidelines vary between the AUA/NCCN and EAU on this approach.

Article Abstract

Germ cell neoplasms of the testis are rare solid tumors predominantly in young men. Seminomas are slightly more frequent than nonseminomatous germ cell tumors. A special feature of seminomas is that they are sensitive to radiation, so that this represents an option in tumor stages with few metastases; however, the guideline recommendation is cautious due to the increased risk of secondary malignancies. In nonmetastasized tumor stages active surveillance is the primary approach to avoid overtreatment of patients. This is also the reason for primary nerve-sparing retroperitoneal lymph node dissection in cases of a low metastasis load. This concept has already been implemented in the American Urological Association (AUA) and National Comprehensive Cancer Network (NCCN) guidelines, whereas in the European Association of Urology (EAU) guidelines it is still considered to be an individual approach.

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http://dx.doi.org/10.1007/s00120-024-02446-9DOI Listing

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