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Beneficial effects of resveratrol on diabetes mellitus and its complications: focus on mechanisms of action. | LitMetric

Beneficial effects of resveratrol on diabetes mellitus and its complications: focus on mechanisms of action.

Naunyn Schmiedebergs Arch Pharmacol

Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

Published: October 2024

AI Article Synopsis

  • Diabetes mellitus is a major global health concern, leading to various complications that affect patients' quality of life.
  • While there are several medications available for diabetes management, there is currently no definitive cure, highlighting the need for new therapies.
  • Resveratrol, a natural polyphenol with antioxidant and anti-inflammatory properties, shows promise as a complementary treatment, and this study examines how it works against diabetes and its related complications.

Article Abstract

Diabetes mellitus (DM) is a significant global health issue, associated with various microvascular and macrovascular complications that significantly impair patients' quality of life as well as healthspan and lifespan. Despite the availability of several anti-diabetic medications with different mechanisms of action, there remains no definite curative treatment. Hence, discovering new efficient complementary therapies is essential. Natural products have received significant attention due to their advantages in various pathological conditions. Resveratrol is a natural polyphenol that possesses antioxidant and anti-inflammatory properties, and its efficacy has been previously investigated in several diseases, including DM. Herein, we aimed to provide a holistic view of the signaling pathways and mechanisms of action through which resveratrol exerts its effects against DM and its complications.

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Source
http://dx.doi.org/10.1007/s00210-024-03527-4DOI Listing

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