AI Article Synopsis
- The study investigates the feasibility of treating Acute Promyelocytic Leukemia (APL) patients entirely on an outpatient basis, focusing on 17 patients treated over 30 years at a clinical center in Puebla.
- All patients received the same outpatient treatment regimen involving ATRA, prednisone, and adriamycin, with 15 out of 17 successfully completing treatment outside of a hospital.
- Notably, 16 of the 17 patients achieved molecular remission, and the 12-month leukemia-free survival rate was 94%, indicating that outpatient treatment could be a viable option, especially in low-resource settings.
Article Abstract
The objective of this study is to explore the possibility of treating APL patients fully as outpatients. A total of 21 consecutive APL patients were identified over 30 years in the Centro de Hematología y Medicina Interna de Puebla, at Clínica Ruiz, but only 17 were studied, treated as outpatients, and followed for at least 1 month; they were observed for median of 95 months, their median age was 27 years and all were treated with ATRA, prednisone, and adriamycin as outpatients. Treatment was completed on an outpatient basis in 15/17 cases. Molecular remission was achieved in 16/17 patients. The median follow-up was 95 months (IQR 19 - 360). The median OS and LFS were not reached, and the 12-month LFS was 94%. We have confirmed that APL can be treated entirely on an outpatient basis: this observation is of utmost relevance in a resource-limited setting, such as those prevailing in low- and middle-income countries.
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| http://dx.doi.org/10.1080/16078454.2024.2417517 | DOI Listing |
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