AI Article Synopsis
- Using mesenchymal stem cells for skin injury treatment faces challenges like ensuring these cells can effectively integrate and maintain their healing properties.
- DNA self-assembly techniques can be leveraged to create multifunctional structures on cell surfaces, boosting their therapeutic potential.
- Engineered stem cells with DNA nanofiber decoration showed improved abilities to scavenge harmful reactive oxygen species, attach to damaged blood vessel cells, and promote new blood vessel formation, making them a promising option for healing wounds in a mouse model.
Article Abstract
A major challenge for stem cell therapies, such as using mesenchymal stem cells to treat skin injuries, is the stable engraftment of exogenous cells and the maintenance of their regenerative capacities in the wound areas. DNA-based self-assembly strategies can be used for artificial and multifunctional cell surface engineering to stabilize and enhance their functions for therapeutic applications. Here, we developed DNA nanofiber-decorated stem cells, in which DNA-based, multivalent fiber-like structures were self-assembled in situ on the cell surfaces. These engineered stem cells have demonstrated robust reactive oxygen species (ROS) scavenging effects, specific adhesion to damaged vascular endothelial cells, and the ability to enhance angiogenesis, which were effective and safe for acute or chronic wound healing in a mouse model with excisional skin injury. This DNA nanostructure-engineered stem cell provides a novel therapeutic platform for the treatment of tissue damage.
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| http://dx.doi.org/10.1021/acs.nanolett.4c03144 | DOI Listing |
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