Introduction: Generalized granuloma annulare (GA) is an uncommon noninfectious granulomatous dermatitis. Phototherapy is often considered first-line therapy, with more evidence for psoralen ultraviolet A than narrowband ultraviolet B (NB-UVB). We aimed to evaluate the effectiveness and safety of NB-UVB in generalized GA and to review the literature.
Materials And Methods: In this observational, retrospective study, 11 patients with generalized GA who received NB-UVB between 2013 and 2023 were evaluated. Data from the patients were obtained from the phototherapy unit and clinical follow-up forms.
Results: Eleven patients, 10 (90.9%) female and 1 (9.1%) male were included in the study. The mean age of the patients was 57.6 ± 7.9 years. The mean disease duration was 26.9 ± 27.9 weeks. Three (27.2%) of the patients had interstitial GA. All patients showed improvement: NB-UVB therapy resulted in complete response in 18.2% of the patients and partial response in 81.8%. The mean number of NB-UVB sessions was 36.4 ± 13.8. The mean cumulative dose was 37.1 ± 25.6 J/cm. There was no significant difference in the mean number of sessions and cumulative dose according to clinical response ( > .05). NB-UVB was extremely well tolerated. After phototherapy, patients were followed for at least 6 months; no relapses were observed.
Conclusion: NB-UVB is an effective and safe treatment option in generalized GA.
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http://dx.doi.org/10.1177/12034754241290811 | DOI Listing |
Molecules
November 2024
School of Chemistry and Environmental Science, Xiangnan University, Chenzhou 423043, China.
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Angew Chem Int Ed Engl
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School of Materials Science and Engineering, Jiangsu Engineering Research Center of Light-Electricity-Heat Energy-Converting Materials and Applications, Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Jiangsu Key Laboratories of Environment-Friendly Polymers, National Experimental Demonstration Center for Materials Science and Engineering, Changzhou University, Changzhou, 213164, P. R. China.
Achieving high efficiency narrowband near-ultraviolet (NUV) emitters in organic light emitting diode (OLED) is still a formidable challenge. Herein, a proof-of-concept hybridized local and charge transfer (HLCT) molecule, named ICz-BO, is prepared and characterized, in which both multiresonant (MR) skeletons are integrated via conjugation connection. A slightly distorted structure and weak intramolecular charge transfer (CT) interaction between two MR subunits lead to a high-lying reverse intersystem crossing (h-RISC) channel of T→S, also evidenced by both experimental and calculated results.
View Article and Find Full Text PDFAntioxidants (Basel)
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Department of Cardiac Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi 110029, India.
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