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Worldview, psychological flexibility, and depression-anxiety-stress in Chinese youth.
Front Psychol
December 2024
School of Philosophy and Social Development, Shandong University, Jinan, China.
Background: The psychological problems among the youth population have received widespread attention in the information age. However, little research has been conducted on the effects and mechanisms of worldview on depression, anxiety, and stress (DAS) among youth. In this study, we aim to investigate the relationship between worldview and DAS among youth.
View Article and Find Full Text PDFMulti-omics analysis and experiments uncover the function of cancer stemness in ovarian cancer and establish a machine learning-based model for predicting immunotherapy responses.
Front Immunol
December 2024
Department of Oncology, Binzhou Medical University Hospital, Binzhou, Shandong, China.
Background: The heterogeneity of cancer makes it challenging to predict its response to immunotherapy, highlighting the need to find reliable biomarkers for assessment. The sophisticated role of cancer stemness in mediating resistance to immune checkpoint inhibitors (ICIs) is still inadequately comprehended.
Methods: Genome-scale CRISPR screening of RNA sequencing data from Project Achilles was utilized to pinpoint crucial genes unique to Ovarian Cancer (OV).
Brain energy homeostasis: the evolution of the astrocyte-neuron lactate shuttle hypothesis.
Korean J Physiol Pharmacol
January 2025
Department of Physiology, Ajou University School of Medicine, Suwon 16499, Korea.
The brain's substantial metabolic requirements, consuming a substantial fraction of the body's total energy despite its relatively small mass, necessitate sophisticated metabolic mechanisms for efficient energy distribution and utilization. The astrocyte-neuron lactate shuttle (ANLS) hypothesis has emerged as a fundamental framework explaining the metabolic cooperation between astrocytes and neurons, whereby astrocyte-derived lactate serves as a crucial energy substrate for neurons. This review synthesizes current understanding of brain energy metabolism, focusing on the dual roles of lactate as both an energy substrate and a signaling molecule.
View Article and Find Full Text PDFSWOOP: top-k similarity joins over set streams.
VLDB J
December 2024
University of Salzburg, Salzburg, Austria.
We provide efficient support for applications that aim to continuously find pairs of similar sets in rapid streams, such as Twitter streams that emit tweets as sets of words. Using a sliding window model, the top- result changes as new sets enter the window or existing ones leave the window. Specifically, when a set arrives, it may form a new top- result pair with any set already in the window.
View Article and Find Full Text PDFEnhancing Drug Discovery and Patient Care through Advanced Analytics with The Power of NLP and Machine Learning in Pharmaceutical Data Interpretation.
SLAS Technol
December 2024
School of science, engineering and environment, University of Salford, United Kingdom. Electronic address:
This study delves into the transformative potential of Machine Learning (ML) and Natural Language Processing (NLP) within the pharmaceutical industry, spotlighting their significant impact on enhancing medical research methodologies and optimizing healthcare service delivery. Utilizing a vast dataset sourced from a well-established online pharmacy, this research employs sophisticated ML algorithms and cutting-edge NLP techniques to critically analyze medical descriptions and optimize recommendation systems for drug prescriptions and patient care management. Key technological integrations include BERT embeddings, which provide nuanced contextual understanding of complex medical texts, and cosine similarity measures coupled with TF-IDF vectorization to significantly enhance the precision and reliability of text-based medical recommendations.
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