AI Article Synopsis
- This study explores whether coffee and caffeine consumption affects the risk of erectile dysfunction (ED) using Mendelian randomization, which analyzes genetic variants related to coffee intake.
- Researchers used genetic information to assess coffee and caffeine's impact, ensuring they excluded factors like diabetes and hypertension that could skew results.
- The findings indicate no significant link between coffee or caffeine consumption and ED risk, with odds ratios suggesting a lack of association in multiple datasets.
Article Abstract
Background: Coffee is a widely consumed beverage with potential benefits for various chronic diseases. Its effect on reducing erectile dysfunction (ED) risk is unclear. This Mendelian randomization (MR) study investigates the impact of coffee/caffeine consumption on ED.
Methods: Two sets of coffee consumption-associated genetic variants at the genome-wide significance level were obtained from recent studies of coffee consumption. Taking into account other sources of caffeine, genetic variants associated with caffeine consumption from tea were also obtained. The inverse variance weighted (IVW) method was utilized as the primary analysis. Sensitivity analysis methods and meta-analysis methods were performed to confirm the robustness of the results, while the genetic variants associated with confounders, e.g., diabetes and hypertension, were excluded.
Results: Genetically predicted coffee/caffeine consumption was unlikely to be associated with the risk of ED in the Bovijn datasets, with similar directional associations observed in the FinnGen datasets. The combined odds ratio for ED was 1.011 (95% CI 0.841-1.216, =0.906) for coffee consumption from the genome-wide meta-analysis, 1.049 (95% CI 0.487-2.260, =0.903) for coffee consumption from the genome-wide association study, and 1.061 (95% CI 0.682-1.651, =0.793) for caffeine from tea.
Conclusion: Using genetic data, this study found no association between coffee/caffeine consumption and the risk of ED.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497819 | PMC |
| http://dx.doi.org/10.3389/fendo.2024.1400491 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Effects of Coffee/Caffeine in Patients with Multiple Sclerosis; A Systematic Review.
J Evid Based Integr Med
October 2024
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Background: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. Caffeine, as the most widely consumed psychoactive substance, has been suggested to have potential effects on the clinical course and disability levels of MS patients. This study aimed to review the current evidence on the effects of coffee/caffeine in patients with MS.
View Article and Find Full Text PDFPotential genetic association between coffee/caffeine consumption and erectile dysfunction: a Mendelian randomization study and meta-analysis.
Front Endocrinol (Lausanne)
October 2024
Department of Urology, The Affiliated Nanchong Central Hospital of North Sichuan Medical College (University), Nanchong, Sichuan, China.
Article Synopsis
- This study explores whether coffee and caffeine consumption affects the risk of erectile dysfunction (ED) using Mendelian randomization, which analyzes genetic variants related to coffee intake.
- Researchers used genetic information to assess coffee and caffeine's impact, ensuring they excluded factors like diabetes and hypertension that could skew results.
- The findings indicate no significant link between coffee or caffeine consumption and ED risk, with odds ratios suggesting a lack of association in multiple datasets.
Effects of Coffee on Gut Microbiota and Bowel Functions in Health and Diseases: A Literature Review.
Nutrients
September 2024
Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.
As one of the most popular beverages in the world, coffee has long been known to affect bowel functions such as motility, secretion, and absorption. Recent evidence obtained in human and animal studies suggests that coffee has modulating impacts on gut microbiota. We aim to present an overview of the specific effects of coffee on gut microbiota composition, diversity, and growth.
View Article and Find Full Text PDFAssociation between tea, coffee and caffeine consumption and risk of female infertility: a cross-sectional study.
Reprod Biol Endocrinol
July 2024
Reproductive Medicine Center, Department of Obstetrics and Gynecology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Objectives: To explore the association between tea, coffee, and caffeine consumption and the risk of female infertility.
Methods: We analyzed data from 2099 females aged 18 to 44 years, participating in the National Health and Nutrition Examination Survey (NHANES) 2013-2018. We used generalized linear models (GLM) and generalized additive model (GAM) to investigate the dose-response relationship between the tea, coffee, and caffeine consumption and infertility, adjusting for potential confounders.
Effect of Coffee and Chocolate Ingestion on Clozapine Dose and on Plasma Clozapine and Norclozapine Concentrations in Clinical Practice.
J Clin Psychopharmacol
March 2024
Department of Psychological Medicine, University of Otago, Wellington, New Zealand.
Background: Some reports point to dietary caffeine intake as a cause of increased plasma clozapine concentrations in certain patients.
Methods: We compared clozapine dose and plasma clozapine and N-desmethylclozapine (norclozapine) concentrations in male and female smokers and nonsmokers in relation to reported (i) coffee (caffeine) and (ii) chocolate (caffeine and theobromine) intake in samples submitted for clozapine therapeutic drug monitoring, 1993-2017.
Results: There was information on coffee ingestion for 16,558 samples (8833 patients) from males and 5886 samples (3433 patients) from females and on chocolate ingestion for 12,616 samples (7568 patients) from males and 4677 samples (2939 patients) from females.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!