AI Article Synopsis
- Neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) are important in assessing outcomes for elderly patients with acute ischemic stroke (AIS), but research on this demographic is limited.
- In a study of 824 elderly AIS patients, significant differences in NLR, LMR, and lymphocyte counts were found between those with good and bad prognoses.
- The combination of NLR and LMR was more effective in predicting poor outcomes than using either measurement alone, indicating that these factors can quantitatively enhance prognosis assessments in elderly AIS patients.
Article Abstract
Background: Neutrophil-to-lymphocyte ratio (NLR) and Lymphocyte-to-monocyte ratio (LMR) have been reported to be associated with outcomes in acute ischemic stroke. However, research on elderly populations remains relatively scarce. We investigated the prognosis of NLR and LMR in elderly with acute ischemic stroke(AIS).
Methods: Based on the modified Rankin Score (mRS) on the 90th day after stroke, patients were divided into group and bad prognosis groups. Multivariate logistic regression analysis and receiver operating curves were used to identify prognostic factors and their predictive powers.
Results: In total, 824 elderly patients with AIS were enrolled between November 2021 and December 2023. Significant differences emerged in the NLR, LMR, and lymphocyte count between the two groups (P<0.05). Binary logistic regression identified NLR, LMR and neutrophil count as independent risk factors for an unfavorable prognosis in elderly patients with AIS. The areas under the curve (AUCs) of NLR, LMR, and the combination of NLR and LMR to discriminate poor function prognosis were 0.703, 0.672, and 0.706, respectively. ROC analysis also showed that combination of NLR and LMR was superior to NLR and LMR alone for predicting AIS.
Conclusion: NLR and LMR independently contribute to an unfavorable prognosis in elderly patients with AIS. The area under the ROC curve (AUC) for the combined NLR and LMR was higher than that for NLR and LMR individually, suggesting that combining these two indicators can improve the predictive ability for clinical outcomes in elderly patients with AIS.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11498037 | PMC |
| http://dx.doi.org/10.2147/CIA.S491753 | DOI Listing |
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