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Application of pedicled supraclavicular flaps in hypopharyngectomy with preservation of laryngeal function.
BMC Surg
December 2024
Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University, No.25, Taiping Street, Jiangyang District, Luzhou, 646000, China.
Objective: To evaluate the efficacy of pedicled supraclavicular flaps in hypopharyngectomy reconstruction, with a focus on preserving laryngeal function.
Methods: From August 2019 to June 2022, 14 patients with primary hypopharyngeal carcinoma who met the inclusion and exclusion criteria and underwent the repair of hypopharyngeal defects using pedicled supraclavicular flaps were included retrospectively. Relevant clinical evaluation indicators include patient characteristics, defect sizes, flap sizes, flap harvesting time, postoperative hospital stay, postoperative complications, recurrence, and survival outcomes.
Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis.
Elife
December 2024
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.
Malaria parasites have evolved unusual metabolic adaptations that specialize them for growth within heme-rich human erythrocytes. During blood-stage infection, parasites internalize and digest abundant host hemoglobin within the digestive vacuole. This massive catabolic process generates copious free heme, most of which is biomineralized into inert hemozoin.
View Article and Find Full Text PDFGargantuan carcinoma ex-pleomorphic adenoma of the submandibular gland: Case report and review of literature.
Am J Otolaryngol
December 2024
Department of Surgery, Division of Otolaryngology, Dayton, OH, USA. Electronic address:
Introduction: Pleomorphic adenoma is the most common neoplasm of the major salivary glands, and can undergo malignant transformation to carcinoma ex-pleomorphic adenoma (CXPA) in untreated patients.
Case Presentation: Our case describes a 56-year-old male with a 15-year history of slowly growing expansive right-sided neck. He underwent excision of the neck mass, neck dissection, and pectoralis flap reconstruction.
Management of Compound Depressed Fractures over Venous Sinuses.
Asian J Neurosurg
December 2024
Department of Neurosurgery, Faculty of Medicine, Cairo University, Egypt.
Article Synopsis
- The study focused on surgical treatment for compound depressed fractures located over the dural venous sinuses, emphasizing how to predict and manage injuries to these sinuses during surgery.
- A total of 34 patients were reviewed, primarily males with an average age of 19.85 years, showing that many experienced isolated head trauma and that the superior sagittal sinus was most commonly affected.
- The findings indicated that while intraoperative sinus tears were common, they could generally be controlled; however, severe injuries leading to massive bleeding and complete sinus tears were rare, especially in cases of significant head trauma.
Altered post-fracture systemic bone loss in a mouse model of osteocyte dysfunction.
JBMR Plus
December 2024
Department of Orthopaedic Surgery, University of California Davis Medical Center, Sacramento, CA 95817, United States.
Femur fracture leads to loss of bone at uninjured skeletal sites, which may increase risk of subsequent fracture. Osteocytes, the most abundant bone cells, can directly resorb bone matrix and regulate osteoclast and osteoblast activity, but their role in systemic bone loss after fracture remains poorly understood. In this study we used a transgenic (TG+) mouse model that overexpresses human B-cell lymphoma 2 (BCL-2) in osteoblasts and osteocytes.
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