The stability of reservoir landslides is determined by the strength of the slide zone. Using both experimental and numerical techniques to analyze the strength of the slide zone has been widely used in the research of reservoir landslides. However, few models consider the strength of the coupling between seepage and shear. This paper aims to analyze the shear strength of slide zone soil combined with different stresses by using the directed shear test and particle flow code PFC. The results indicated that slide zone soil clearly experienced the strain-hardening without seepage. While a specific strain-softening phenomenon was observed because the introduction of seepage reduced the shear strength significantly, the internal friction angle demonstrated a higher sensitivity to seepage stress compared to cohesion as the seepage stress increased. The direction and amount of flow velocity dynamically alter during the shear process, as revealed by numerical simulation results, suggesting that the shear strength was nonlinear with increasing seepage stress and changed structure. It can be assumed that seepage deterioration in the Huangtupo landslide is a dynamic process that influences the structure, strength and permeability characteristics.
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http://dx.doi.org/10.1038/s41598-024-77163-6 | DOI Listing |
Cytotechnology
February 2025
Interventional Radiology Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, H-118, New York, NY 10065 USA.
The aim of this study was to evaluate if the Ki-67 labeling index (LI) on immediate pre-ablation biopsies of colorectal liver metastases (CLM) is associated with the presence of viable tumor cells in subsequent ablation zone biopsies and/or local tumor progression-free survival (LTPFS). Biopsies of CLM were performed before and after microwave ablation (MWA), as part of a prospective clinical trial between October 2013 and May 2019. Pre-ablation biopsy slides were examined for the Ki-67 LI using light microscopy.
View Article and Find Full Text PDFPLoS One
December 2024
Department of Biology, College of Natural Sciences, Arba Minch University, Arba Minch, Ethiopia.
Introduction: Thyroid and salivary gland cytopathology frequently present diagnostic challenges due to complex presentations, overlapping features between benign and malignant conditions, particularly with grey-zone entities and rare pathologies. To address these issues, the 45th European Congress of Cytology (ECC) held a slide seminar focused on challenging cases. This article reviews key findings from the six cases discussed, emphasizing the importance of a comprehensive diagnostic approach.
View Article and Find Full Text PDFBiosens Bioelectron
March 2025
Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA; School of Biomedical Engineering, Colorado State University, CO, USA, 80523; Department of Chemical and Biological Engineering, Colorado State University, CO, USA, 80523. Electronic address:
The COVID-19 pandemic highlighted the need for rapid and sensitive diagnostic tools. In this work, the Magnetophoretic Slider Assay (MeSA) was integrated with electrochemical detection (eMeSA) using screen-printed carbon electrodes for the first time for the detection of SARS-CoV-2 nucleocapsid protein (NP). A sandwich enzyme-linked immunosorbent assay (ELISA) was performed on streptavidin-labeled magnetic beads (MBs).
View Article and Find Full Text PDFGigascience
January 2024
Phycology Group, Faculty of Biology, University of Duisburg-Essen, 45141 Essen, Germany.
Background: Diatoms are microalgae with finely ornamented microscopic silica shells. Their taxonomic identification by light microscopy is routinely used as part of community ecological research as well as ecological status assessment of aquatic ecosystems, and a need for digitalization of these methods has long been recognized. Alongside their high taxonomic and morphological diversity, several other factors make diatoms highly challenging for deep learning-based identification using light microscopy images.
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