Wnt morphogens induce signaling via binding their extracellular receptors. Here, we discuss several recent structural studies showing how Wnts engage their receptors frizzled (FZD) and low-density lipoprotein receptor-related protein 5/6 (LRP5/6), how Cachd1 has been shown as an alternative initiator of Wnt signaling, and how lipidated Wnt may be produced and secreted from the cell.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624986 | PMC |
| http://dx.doi.org/10.1016/j.tibs.2024.09.007 | DOI Listing |
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