AI Article Synopsis
- The study investigates the presence and importance of autoantibodies against lysobisphosphatidic acid (aLBPA) in patients with antiphospholipid syndrome (APS).
- It compares 91 patients with antiphospholipid antibodies—60 symptomatic and 31 asymptomatic—to 33 controls, finding a higher prevalence of aLBPA among patients.
- The research suggests that testing for aLBPA alongside conventional antiphospholipid antibodies may help in managing APS, especially in deciding if asymptomatic patients should receive preventive treatment.
Article Abstract
Objectives: To assess the prevalence and clinical significance of autoantibodies against lysobisphophatidic acid (aLBPA) in patients with antiphospholipid syndrome (APS).
Methods: We conducted a retrospective analysis involving 91 patients with persistent conventional antiphospholipid antibodies (aPL): 60 patients with at least one clinical event of APS (symptomatic group) and 31 without (asymptomatic group), as well as 33 aPL-negative controls. Detection of aLBPA in serum samples was performed using an enzyme-linked immunosorbent assay (ELISA) specifically designed for this study.
Results: The prevalence of aLBPA is significantly higher in patients with persistent aPL than that of the control group (p< 0.0001). Among patients with persistent aPL, our findings reveal a significantly higher prevalence of aLBPA in asymptomatic patients compared with their symptomatic counterparts (p= 0.027). Notably, patients positive for IgG aPL alone demonstrated a greater likelihood of presenting clinical events suggestive of APS.
Conclusion: The combined assay of aLBPA and conventional aPL could be used to stratify patients with persistent aPL. This combined approach could serve as a valuable tool in the management of this complex autoimmune disease, particularly in guiding decisions regarding the initiation of primary thromboprophylaxis in asymptomatic patients with persistent aPL.
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| http://dx.doi.org/10.1093/rheumatology/keae588 | DOI Listing |
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