AI Article Synopsis
- * The study showcases a successful diagnosis of epithelioid angiosarcoma (EAS) using lung resection samples, combining visual inspection, imprint cytology, and specific immunocytochemical markers.
- * The findings highlight the effectiveness of cytological specimens for diagnosing EAS, providing a valuable alternative when traditional tissue samples are difficult to obtain.
Article Abstract
Background: Angiosarcoma, a very rare malignant tumor constituting 2%-4% of soft tissue sarcomas, manifest in diverse organs including skin, soft tissues, and bones. Histologically, angiosarcoma presents a wide range of morphologies, with epithelioid angiosarcoma (EAS) resemblance to carcinoma. The difficulty arises from the shared epithelial-like morphology and expression of epithelial markers in immunohistochemistry.
Case: This study reports a case where EAS diagnosis was achieved through a combination of gross findings in a lung resection sample, imprint cytology, and immunocytochemistry. Imprint cytology revealed clusters of epithelioid cells, while immunocytochemistry showed positive results for CD31, ERG, Fli-1, and AE1/AE3, proving instrumental in diagnosing EAS. The described immunocytochemical protocol facilitates prompt diagnosis exclusively through cytology samples.
Conclusion: This report emphasizes the potential for diagnosing EAS using cytological specimens, which is especially useful in cases where obtaining tissue samples proves challenging.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11498060 | PMC |
| http://dx.doi.org/10.1002/cnr2.70014 | DOI Listing |
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