AI Article Synopsis
- * NIFTP is diagnosed through histological examination, avoiding high-risk mutations, and has a low chance of recurrence, leading to less aggressive surgical treatment strategies compared to traditional thyroid cancers.
- * The review aims to provide a detailed overview of NIFTP, covering its characteristics, diagnosis, management, and future research possibilities while highlighting challenges in improving preoperative diagnostics and follow-up care.
Article Abstract
Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a recently defined thyroid nodule category characterized by follicular architecture with papillary nuclear features but lacking classical papillary carcinoma features like papillae or psammoma bodies. The diagnosis of NIFTP is based on histological examination and excludes cases with high-risk mutations like BRAFV600E. NIFTP carries a low risk of recurrence and distant metastasis, prompting a more conservative surgical approach compared to classical papillary thyroid carcinoma. The management of NIFTP typically involves lobectomy with postoperative monitoring of thyroglobulin levels and performing neck ultrasounds. While the identification of NIFTP represents a significant advancement in thyroid cancer diagnosis, challenges remain in refining preoperative diagnostic tools and establishing optimal long-term follow-up strategies. The objective of this review is to provide a comprehensive overview of NIFTP, including its histopathological characteristics, molecular profile, clinical presentation, diagnostic criteria, management strategies, and future research directions.
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| http://dx.doi.org/10.1007/s00428-024-03953-y | DOI Listing |
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