AI Article Synopsis
- A recent review examined the link between COVID-19 vaccination and the development of aplastic anemia (AA) in patients infected with SARS-CoV-2, analyzing 26 research studies involving 53 cases.
- The review highlighted diverse causes of AA and discussed potential new factors, including SARS-CoV-2 and COVID-19 vaccines, while addressing a gap in current medical knowledge.
- Although a direct mechanism connecting AA with these factors isn’t confirmed, the review explored possible biological mechanisms behind this association to enhance understanding in medical practice.
Article Abstract
Patients infected with SARS-CoV-2 and vaccinated against COVID-19 could develop aplastic anemia (AA). Comprehensive review and analysis were conducted through a selective literature search in PubMed, Scopus, EMBASE, and Web of Science. For this analysis, 26 studies were included, comprising 16 case reports, 7 case series, and 3 observational studies, totaling 53 patients. The causes of acquired or idiopathic AA are diverse; this review presents recent findings, including possible new etiologies such as SARS-CoV-2 infection and COVID-19 vaccines. This possible association is explored, addressing the existing gap, and aiming to improve daily medical practice. This article reviews the relationship between AA and SARS-CoV-2 infection, as well as COVID-19 vaccines, analyzing cases of de novo occurrence and relapses of AA. Although a definitive mechanistic link has not yet been established, possible underlying pathophysiological mechanisms are explored.
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| http://dx.doi.org/10.1007/s00277-024-06052-9 | DOI Listing |
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