AI Article Synopsis
- - Stable organic radicals are being explored for their potential as high-fluorescence dyes, specifically looking at transitions from the ground state to an excited state.
- - A new compound called TFC-I was synthesized, achieving nearly 100% photoluminescence quantum yield (PLQY) and was incorporated into nanoparticles, creating P-TI, which showed strong features like high photostability and efficient ROS generation.
- - P-TI proved effective for targeted photodynamic therapy, deep tissue imaging, and demonstrated good safety in tests, highlighting the benefits of using organic radicals in medical applications.
Article Abstract
Stable organic radicals, with unique electronic transitions from the ground state (D) to the doublet excited state (D), show promise as high-fluorescence quantum yield dyes. While organic small-molecule photosensitizers (PSs) have advanced for tumor photodynamic therapy (PDT), opportunities exist to enhance their performance and functionality. Herein, we synthesized Thiele's fluorocarbon derivative diradicaloid TFC-I with nearly 100% PLQY and integrated it into amphiphilic polypeptide nanoparticles, P-TI, using a precursor-doping approach. P-TI demonstrated notable features including high photostability, aggregation-induced emission, bright near-infrared fluorescence, substantial quantum yield (37% PLQY), robust near-infrared two-photon absorption (∼400 GM cross section), and superior ROS generation compared to commercial PSs. and experiments confirmed that P-TI performed well in mitochondria-targeted PDT, two-photon fluorescence imaging, and biosafety. This work highlights the use of organic stable radicals with precursor-doping for efficient PDT and deep tumor tissue imaging.
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| http://dx.doi.org/10.1021/acsami.4c13338 | DOI Listing |
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