AI Article Synopsis

  • * The study involved 24 CM patients and 15 healthy controls, who were divided into responder and non-responder groups based on their treatment outcomes; various imaging techniques were used to measure brain structure and function before and after treatment.
  • * Results indicated that while there were no significant changes in gray matter volume or structural connectivity post-treatment, functional connectivity improved between specific brain regions, suggesting that measuring this connectivity could be effective for assessing treatment impacts in CM patients.

Article Abstract

Patients with chronic migraine (CM) often exhibit structural and functional alterations in pain-matrix regions, but it remains unclear how preventive treatment affects these changes. Therefore, this study aimed to investigate the structural and functional changes in pain-matrix regions in CM patients after 6-month treatment. A total of 24 patients with CM and 15 healthy controls were recruited for this study. Patients were divided into responder group (N = 9) and non-responder group (N = 15). After completing the Migraine Disability Assessment (MIDAS) questionnaire, all patients underwent whole-brain high-resolution T1-weighted images, diffusion-weighted imaging, and resting-state functional magnetic resonance imaging at baseline and 6-month follow-up. Whole brain gray matter volume and white matter diffusion indices were analyzed using voxel-based analysis. Structural and functional connectivity analyses were performed to understand brain changes in patients after 6-month preventive treatment. The responder group exhibited significantly higher MIDAS scores than the non-responder group at baseline, but no significant difference between the two groups at follow-up. No significant interval change was noted in gray matter volume, white matter diffusion indices, and structural connectivity in CM patients after 6-month treatment. Nonetheless, the functional connectivity was significantly increased between occipital, temporal lobes and cerebellum, and was significantly decreased between parietal and temporal lobes after 6-month preventive treatment. We concluded that resting-state functional connectivity was suitable for investigating the preventive treatment effect on CM patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618484PMC
http://dx.doi.org/10.1002/kjm2.12903DOI Listing

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