AI Article Synopsis
- After a first seizure, anti-seizure medications (ASMs) can influence the likelihood of additional seizures, leading to a study that analyzes brain network changes using fMRI data from 28 participants before and during ASM therapy.
- The research found that ASM treatment increased the clustering coefficient and decreased network path length, indicating more efficient brain connections, with the greatest changes observed in specific brain regions linked to seizure activity.
- The findings suggest that individuals with recurrent seizures exhibit more significant network changes after ASM treatment, highlighting the need for larger studies to better understand the relationship between ASM effects and long-term seizure outcomes.
Article Abstract
After a first epileptic seizure, anti-seizure medications (ASMs) can change the likelihood of having a further event. This prospective study aimed to quantify brain network changes associated with taking ASM monotherapy. We applied graph theoretical network analysis to longitudinal resting-state functional MRI (fMRI) data from 28 participants who had recently experienced their first seizure. Participants were imaged before and during long-term ASM therapy, with a mean inter-scan interval of 6.9 months. After commencing ASM, we observed an increase in the clustering coefficient and a decrease in network path length. Brain changes after ASM treatment were most prominent in the superior frontoparietal and inferior fronto-temporal regions. Participants with recurrent seizures display the most pronounced network changes after ASM treatment. This study shows changes in brain network function after ASM administration, particularly in participants with recurrent seizures. Larger studies that ideally include control cohorts are required to understand further the connection between ASM-related brain network changes and longer-term seizure status.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11495098 | PMC |
| http://dx.doi.org/10.1093/braincomms/fcae328 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!