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Alcohol Abstinence, Adherence, and Attitudes toward Disulfiram Treatment for Alcohol Dependence among Patients Attending a Tertiary Care Setting in North India. | LitMetric

AI Article Synopsis

  • Disulfiram is the first FDA-approved medication for alcohol dependence, acting as a deterrent, but there's limited research on its effectiveness in low-income and middle-income countries.
  • A study assessed participants' alcohol abstinence and adherence to disulfiram at intervals of 4, 12, and 24 weeks, using self-reports and the Treatment Compliance Assessment Scale.
  • Results showed that around 62% of participants remained abstinent after 12 weeks, dropping to 46% at 24 weeks, with adherence declining from 36.3% to 57.2% during the same period, highlighting the need for better support for patients on disulfiram.

Article Abstract

Background: Disulfiram is the first Food and Drug Administration (FDA)-approved drug for the treatment of alcohol dependence, primarily acting as a deterrent agent. The available literature on disulfiram treatment for alcohol dependence among individuals in low-income and middle-income countries is scarce, while numerous factors impact the acceptance and adherence to such treatment.

Methods: The study utilized a purposive sampling methodology. The participants were contacted by telephone at 4 weeks, 12 weeks, and 24 weeks after the initiation of disulfiram treatment. Alcohol abstinence was calculated using the self-reported total alcohol-free days, and adherence and attitudes toward disulfiram treatment were measured using the Treatment Compliance Assessment Scale (TCAS).

Findings: The participants had a mean age of 39.30±7.7 years. Nearly 62% and 46% of the subjects reported maintenance of alcohol abstinence after initiation of 12 and 24 weeks of disulfiram treatment, respectively. The proportion of non-adherent subjects increased from 36.3% to 57.2% during the 12-week and 24-week follow-up periods. Attitudes toward disulfiram treatment varied significantly across different time points. A strong positive correlation was observed in the alcohol abstinence, adherence, and attitude scores at different time points (<0.01).

Conclusion: The present study's findings unveiled that nearly 60% and 40% of the study subjects were maintaining alcohol abstinence and adherence at 12 weeks and 24 weeks after initiation of disulfiram treatment, respectively. Disulfiram could be a viable psychological tool for alcohol abstinence, but objective measurements are required to underpin its utility in this setting.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491862PMC
http://dx.doi.org/10.34172/ahj.1537DOI Listing

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