Postsurgical pyoderma gangrenosum (PSPG) is a rare, ulcerative skin condition that presents a diagnostic challenge due to its similar presentation to infectious etiologies in the postsurgical period-often leading to gratuitous and unnecessary surgery and antibiotic use. We report a 37-year-old female with breast cancer who received neoadjuvant chemotherapy and immunotherapy and underwent bilateral skin-sparing mastectomies who developed delayed bilateral mastectomy skin flap necrosis secondary to PSPG. This case had rare factors associated with the development of PSPG such as preoperative systemic therapy and a familial component. This case underscores the importance of early recognition of this rare disease and appropriate management of PSPG to prevent unnecessary interventions and ensure an optimal outcome.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11495327 | PMC |
| http://dx.doi.org/10.1093/jscr/rjae667 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Postsurgical pyoderma gangrenosum after mastectomy with a familial component.
J Surg Case Rep
October 2024
Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, United States.
Postsurgical pyoderma gangrenosum (PSPG) is a rare, ulcerative skin condition that presents a diagnostic challenge due to its similar presentation to infectious etiologies in the postsurgical period-often leading to gratuitous and unnecessary surgery and antibiotic use. We report a 37-year-old female with breast cancer who received neoadjuvant chemotherapy and immunotherapy and underwent bilateral skin-sparing mastectomies who developed delayed bilateral mastectomy skin flap necrosis secondary to PSPG. This case had rare factors associated with the development of PSPG such as preoperative systemic therapy and a familial component.
View Article and Find Full Text PDFAssessing the role of wound debridement in pyoderma gangrenosum-A retrospective cohort study.
Wound Repair Regen
November 2024
Department of Internal Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Article Synopsis
- The study examined the effects of wound debridement on patients with pyoderma gangrenosum (PG), highlighting the concern of pathergy (worsening of wounds due to intervention).
- Among 104 patients analyzed, those undergoing debridement showed significantly lower remission rates (60.53%) compared to those treated with immunosuppression alone (87.88%), along with a longer average time to remission (12.3 months vs. 8.67 months).
- The results indicated higher rates of disease progression and the need for additional procedures in the debridement group, suggesting that debridement may worsen healing outcomes in PG and should be avoided in treatment.
Development of Postsurgical Pyoderma Gangrenosum with New Keloid after Keloid Resection.
Adv Skin Wound Care
September 2024
At Nippon Medical School, Musashi Kosugi Hospital, Kanagawa, Japan, Yusaku Saijo, MD, is Plastic Surgeon, Department of Plastic and Reconstructive Surgery; Hiroaki Kuwahara, MD, PhD, is Plastic Surgeon, Department of Plastic and Reconstructive Surgery; and Keigo Ito, MD, PhD, is Associate Professor, Department of Dermatology and Dermatopathology. Rei Ogawa, MD, PhD, FACS, is Professor, Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School Hospital, Tokyo. Satoshi Akaishi, MD, PhD, is Professor, Department of Plastic and Reconstructive Surgery, Nippon Medical School, Musashi Kosugi Hospital.
Article Synopsis
- Keloids are raised scars that can develop from various skin traumas, while pyoderma gangrenosum (PG) is a painful ulcerative skin condition linked to immune dysfunction; both have unclear causes.
- A notable case involved a 24-year-old woman with a keloid on her chest that revealed a PG ulcer upon surgical removal, leading to complex post-surgery complications.
- After treatment for PG, relapsed keloids appeared, suggesting that careful management is key for patients with PG and a history of keloid formation, with options like corticosteroid taping being considered the safest.
The role of split-thickness skin grafting in the treatment of vasculitic and pyoderma gangrenosum ulcers in a multidisciplinary wound centre.
Int Wound J
June 2024
Department of Dermatology, Tampere University Hospital, Tampere, Finland.
Vasculitic and pyoderma gangrenosum ulcers are traditionally treated with immunosuppressants, and the role of surgery in the treatment of these atypical ulcers remains unclear. This study aimed to investigate the need for surgical intervention as well as the outcome and safety of skin grafting in the treatment of 46 patients with vasculitic ulcers and 34 with pyoderma gangrenosum ulcers using data recorded in the validated Wound Registry. Of the 80 patients with atypical ulcers, 14% (n = 11) were treated surgically; these patients were older (p = 0.
View Article and Find Full Text PDFPostsurgical Pyoderma Gangrenosum After Penile Inversion Vaginoplasty: Case With Review of Diagnostic and Management Strategies.
Eplasty
May 2024
Division of Plastic Surgery, Department of Surgery, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas.
Background: Postsurgical pyoderma gangrenosum (PSPG) is a highly uncommon and unpredictable wound healing complication. Rapid progression of ulcers at incisions can cause unfettered dehiscence. Most commonly, PSPG involves breast procedures; however, in this work, we detail a case of a patient who developed PSPG 10 days postoperatively after penile inversion vaginoplasty.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!