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Comparison of the biocompatibility and osteogenesis potential of whitlockite and an activin A/BMP2 chimera using a rat calvarial defect model: a pilot study. | LitMetric

AI Article Synopsis

  • - The study aimed to assess the effectiveness of whitlockite nanoparticles and an activin A/BMP2 chimera (AB204) in enhancing bone regeneration in rat calvarial defects.
  • - Researchers created 5mm circular defects in 8 rats and divided them into three groups to analyze bone healing over 2 and 4 weeks using different materials.
  • - Results showed the BO/WH/AB204 group had significantly better bone healing compared to the other two groups, indicating that AB204 contributes positively to bone regeneration.

Article Abstract

Purpose: The aim of this study was to evaluate bone regeneration using whitlockite (WH) nanoparticles, collagenated bovine bone mineral, and an activin A/BMP2 chimera (AB204) on calvarial defects in rats.

Methods: This study was conducted using 8 rats. Five-millimeter circular defects were formed on each side of the calvaria. The defects were randomly assigned to 3 groups (BO group: BioOss collagen, BO/WH group: BO + WH, and BO/WH/AB204 group: BO + WH + AB204). After healing periods of 2 and 4 weeks, histological and histomorphometric analyses were performed after sacrifice.

Results: The BO/WH/AB204 group showed superior bone healing compared to the other 2 groups (BO and BO/WH). In the BO and BO/WH groups, new bone formation was found in the defect margin. However, in the BO/WH/AB204 group, new bone was observed on the upper and lower surfaces of the grafted area. The new bone area of the BO/WH/AB204 group at 4 weeks was significantly higher than that of the same group at 2 weeks. At 4 weeks, the total augmented area and material area in the BO/WH/AB204 group were significantly lower than the corresponding values at 2 weeks.

Conclusions: The BO/WH/AB204 group showed superior results of bone regeneration at 2 and 4 weeks compared to the BO and BO/WH groups. AB204 seems to play an important role in bone regeneration.

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Source
http://dx.doi.org/10.5051/jpis.2304280214DOI Listing

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