AI Article Synopsis
- The study focuses on the liver injury caused by Polygonum multiflorum (PM-DILI), which limits its clinical use.
- Researchers analyzed the harmful components known as dianthrones in raw and processed P. multiflorum using advanced chromatography techniques.
- Results showed that as processing cycles (steaming and sunning) increased, the levels of dianthrones decreased, leading to lower toxicity in liver cells and zebrafish, supporting safer clinical applications.
Article Abstract
Background: Polygonum multiflorum-induced liver injury (PM-DILI) has significantly hindered its clinical application and development.
Methods: This study investigates the variation in content and toxicity of dianthrones, the toxic components of P. multiflorum, during different processing cycles. We employed the ultra-high-performance liquid chromatography triple quadrupole mass spectrometry method to quantify six dianthrones in raw P. multiflorum and formulations processed with a method called nine cycles of steaming and sunning. Additionally, toxicity assessments were conducted using human normal liver cell line L02 and zebrafish embryos.
Results: Results indicate a gradual reduction in dianthrones content with increasing processing cycles. Processed formulations exhibited significantly reduced cytotoxicity in L02 cells and hepatotoxicity in zebrafish embryos.
Conclusions: Our findings elucidate the relationship between processing cycles and P. multiflorum toxicity, providing theoretical support for its safe use.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ame2.12474 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!