AI Article Synopsis
- The review highlights key advancements in 2023 regarding Interstitial Lung Disease (ILD), emphasizing the link between pollution and genetic factors that heighten the risk of Idiopathic Pulmonary Fibrosis (IPF).
- It points out that malnutrition, as a comorbidity, has not been fully acknowledged in ILD cases.
- The study also mentions novel genes related to IPF, signaling pathways influencing lung remodeling, new methods for disease monitoring, and innovative treatments like inhaled pirfenidone and efzofitimod for sarcoidosis.
Article Abstract
In this review, we have discussed several important developments in 2023 in Interstitial Lung Disease (ILD). The association of pollution with genetic predispositions increased the risk of Idiopathic Pulmonary Fibrosis (IPF). An interesting comorbidity of malnutrition was not adequately recognized in ILD. Novel genes have been identified in IPF involving predominantly short telomere length and surfactant protein production leading to alveolar epithelial cell dysfunction. Genetics also predicted progression in IPF. Crosstalk between vascular endothelial cells and fibroblasts in IPF mediated by bone morphogenic protein signalling may be important for remodelling of the lung. A novel modality for monitoring of disease included the 4-min gait speed. New treatment modalities include inhaled pirfenidone, efzofitimod, for sarcoidosis, and earlier use of immunosuppression in connective tissue disease-ILD.
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| http://dx.doi.org/10.1111/resp.14848 | DOI Listing |
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