AI Article Synopsis
- An adapted in vitro pharmacology profiling panel (APPP) was created to evaluate the effects of 129 cosmetic chemicals, including both traditional pharmaceutical targets and additional targets related to systemic toxicities.
- The study demonstrated strong internal data consistency, with reproducible results across different testing concentrations and compatibility with existing ToxCast and drug excipient data.
- The findings highlight how this panel can aid in risk assessments for cosmetic chemicals without the need for new animal testing, supported by case studies and discussions of new methodologies.
Article Abstract
An adapted in vitro pharmacology profiling panel (APPP) was developed that included targets used in the pharmaceutical industry alongside additional targets whose cellular functions have been linked to systemic toxicities. This panel of 83 target assays was used to profile the activities of 129 cosmetic relevant chemicals with diverse chemical structures, physiochemical properties and cosmetic use types. Internal data consistency was proved robust, as evidenced by the reproducibility between single concentration and concentration-response data and showed good concordance with data reported in the ToxCast and drug excipient datasets. We discuss how the data can be analyzed and multiple potential contexts of use illustrated by case studies, alongside other new approach methodologies, to support cosmetic chemical risk assessments that do not require data from new animal studies.
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| http://dx.doi.org/10.1016/j.taap.2024.117131 | DOI Listing |
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