This perspective addresses the key challenge of advancing the use of Critical Raw Materials (CRMs) and proposes a transition towards circular raw material management. In the context of our current economy, the unsustainable consumption, environmental degradation, geopolitical risks, and economic vulnerabilities associated with CRMs highlight the limitations in ensuring long-term CRM availability, emphasizing the environmental, social, and economic implications. In response, this perspective underlines a multifaceted technological approach to mitigate CRM criticality, focusing on reducing CRM use, substituting CRMs with less critical materials, and enhancing recovery and recycling processes, with Design for Circularity as the most impactful solution. The latter advocates for a paradigm shift in product design and material utilization, emphasizing principles like modular design, product life extension, and the transition from product ownership to service models. Such a holistic approach is not only crucial for sustainable CRM management, but is also key to fostering a resilient and low-carbon economy.
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http://dx.doi.org/10.1002/cssc.202401170 | DOI Listing |
Front Plant Sci
January 2025
Institute of Food Crops, Hainan Academy of Agricultural Sciences/Hainan Key Laboratory of Crop Genetics and Breeding, Haikou, China.
Introduction: Sweet potato is an important food, feed and industrial raw material, and its tubers are rich in starch, carotenoids and anthocyanins.
Methods: To elucidate the gene expression regulation and metabolic characteristics during the development of sweet potato tubers, transcriptomic and metabolomic analyses were performed on the tubers of three different sweet potato varieties at three developmental stages (70, 100, and 130 days (d)).
Results: RNA-seq analysis revealed that 16,303 differentially expressed genes (DEGs) were divided into 12 clusters according to their expression patterns, and the pathways of each cluster were annotated.
Vet Med Int
January 2025
Faculty of Veterinary Medicine, Hawassa University, P.O. Box 05, Hawassa, Ethiopia.
A cross-sectional study was conducted to determine the seroprevalence and potential risk factors of camel brucellosis and to assess public health awareness of the disease in the selected kebele of Arero District, Borena Zone, Southern Ethiopia. A total of 313 blood samples were collected from selected camels using a systematic random sampling technique. The serum samples underwent initial screening for brucellosis using the rose Bengal plate test (RBPT), with further confirmation through the indirect enzyme-linked immunosorbent Assay (i-ELISA).
View Article and Find Full Text PDFJ Toxicol Pathol
January 2025
Department of Molecular Pathology, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, Japan.
Occupational exposure to aromatic amines is a major risk factor for urinary bladder cancer. Our previous studies showed that acetoaceto--toluidine, which is produced using -toluidine as a raw material, promotes urinary bladder carcinogenesis in rats. We also found high concentrations of -toluidine, a human bladder carcinogen, in the urine of acetoaceto--toluidine-treated rats, indicating that urinary -toluidine derived from acetoaceto--toluidine may play an important role in bladder carcinogenesis.
View Article and Find Full Text PDFAnn Med
December 2025
Clinical Center for Intelligent Rehabilitation Research, Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Tongji University, Shanghai, China.
Background: Cardiovascular disease (CVD) is the top cause of death in China. We aimed to identify trends in cause-specific CVD mortality in a rapidly developing country, thereby providing evidence for CVD prophylaxis.
Materials And Methods: Using raw data from the Chinese National Mortality Surveillance (CNMS) system, we assessed the mortalities of all CVD and cause-specific CVD during 2009-2019.
Clin Pharmacokinet
January 2025
Centre for Human Drug Research (CHDR), Leiden, The Netherlands.
Background And Objective: N,N-Dimethyltryptamine (DMT) is currently being studied for its therapeutic potential in various psychiatric disorders. An understanding of its pharmacokinetics (PK) is essential to determine appropriate dose ranges in future clinical studies. We conducted a systematic literature review on the PK of DMT.
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