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| http://dx.doi.org/10.1001/jamanetworkopen.2024.40414 | DOI Listing |
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Pharmacokinetics of Enteral Lormetazepam in Mechanically Ventilated ICU Patients with COVID-19: An Adjunct Sedative Study.
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December 2024
Department of Clinical Pharmacy, VieCuri Medical Center Venlo, 5900 BX, Venlo, The Netherlands.
Background And Objective: During the coronavirus disease 2019 (COVID-19) pandemic, sedative prescriptions surged, leading to shortages of midazolam. This study investigates lormetazepam as an adjunct sedative alternative to midazolam for mechanically ventilated patients with COVID-19. We aimed to determine the clinical pharmacokinetics (PK) of enterally administered lormetazepam and provide dosing recommendations.
View Article and Find Full Text PDFThe Effect of Obesity on Postoperative Analgesia Practices and Complications Following Endoscopic Sinus Surgery: A Propensity Score-Matched Cohort Study.
Ann Otol Rhinol Laryngol
February 2025
Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
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Use of Prescription Antiemetics Among US Commercially Insured Pregnant Patients, 2005-2019.
JAMA Netw Open
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Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville.
Association Between Medical Marijuana Cardholder Status and Antiemetic Overuse.
Cannabis Cannabinoid Res
October 2024
Department of Family and Preventive Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
The conscientious prescribing of antiemetics by chemotherapy-induced nausea and vomiting (CINV) risk was highlighted in the American Society of Clinical Oncology (ASCO) "Choosing Wisely" recommendations. The pharmacologic properties of medical marijuana (MMJ) may allow for decreased incidence of CINV; however, little is known about the effects of MMJ on the use of antiemetics. This study aimed to determine if MMJ cardholder status, which enables access to MMJ, is associated with antiemetic overuse among patients with cancer.
View Article and Find Full Text PDFBenzodiazepine Utilization in Ischemic Stroke Survivors: Analyzing Initial Excess Supply and Longitudinal Trends.
Stroke
November 2024
Department of Neurology (V.L.T., J.D.B., M.A.D., L.M.V.R.M.), Massachusetts General Hospital, Harvard Medical School, Boston.
Article Synopsis
- Benzodiazepines are often prescribed to older patients after an acute ischemic stroke, despite guidelines advising against this for those aged 65 and over.
- An analysis of Medicare claims from 2013 to 2021 showed that 4.9% of stroke survivors started benzodiazepine treatment, with higher initiation rates among females and in the southeastern US.
- Although there was a slight decline in new prescriptions over the years, many patients received overly long prescriptions, indicating a need for better prescribing policies.
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