Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/dote/doae092 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The enigma of the perfect gastric conduit-invited editorial.
Dis Esophagus
January 2025
Department of General Surgery, Guy's and St Thomas' NHS Trust, London, SE1 7EH, UK.
What Targets Somatic Hypermutation to the Immunoglobulin Loci?
Viral Immunol
May 2020
Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
One of the most profound enigmas in B cell biology is how activation-induced deaminase (AID) is targeted to a very small region of DNA in the immunoglobulin loci. Two specific regions are singled out: the variable region of 2 kb that contains rearranged genes on the heavy, light, and light chain loci, and the switch region of ∼4 kb that contains an extensive stretch of G:C rich DNA on the heavy chain locus. Transcription is required for AID recruitment; however, many genes are also highly transcribed and do not undergo the catastrophic mutagenesis that occurs in variable and switch regions.
View Article and Find Full Text PDFFundamental asymmetry of insertions and deletions in genomes size evolution.
J Theor Biol
December 2019
School of Life Sciences and MOE Key laboratory of Molecular Enzymology and Engineering, Jilin University 2699 Qianjin Street, Changchun, China 130012. Electronic address:
The origin of large genomes that underlies the long standing "C-value enigma" is only partially explained by selfish DNA. We investigated insertions and deletions (indels) of nucleotides and discussed their relevance in size evolution of random biological sequences (RBS) and genomes. By developing a probabilistic model of RBS based on size evolution of expandable sites in a thought perfect genome, it was found that insertion bias engenders exponential increase of average RBS sizes.
View Article and Find Full Text PDFGenome dynamics over evolutionary time: "C-value enigma" in light of chromosome structure.
Mutat Res Genet Toxicol Environ Mutagen
December 2018
Department of Life Sciences, College of Health and Life Sciences, Brunel University London, UB8 3PH, Uxbridge, UK. Electronic address:
Eukaryotic genome evolution integrates processes behind (i) chromosome plasticity (change in chromosome structure and number), (ii) genome stability maintenance (perfect stability would prevent adaptive processes) and (iii) genome size. Relationships between these variables remain enigmatic, hence the term "C-value enigma". This term reflects an apparent lack of correlation between genome size and perceived organismal complexity, replacing an older term "C-value paradox".
View Article and Find Full Text PDFPavlovian-instrumental interactions in active avoidance: The bark of neutral trials.
Brain Res
June 2019
Gatsby Computational Neuroscience Unit, University College London, United Kingdom.
In active avoidance tasks, subjects have to learn to execute particular actions in order to avoid an aversive stimulus, such as a shock. Such paradigms pose a number of psychological and neural enigmas, and so have attracted substantial computational interest. However, the ratio of conjecture to confirmation remains high.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!